ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

701–720 of 1,186 studies

E3 PreliminaryCohortPEM requiredObservational

Atopy and Elevation of IgE, IgG3, and IgG4 May Be Risk Factors for Post COVID-19 Condition in Children and Adolescents.

Körner, Robert Walter, Bansemir, Ole Yannick, Franke, Rosa et al.·Children (Basel, Switzerland)·2023

This study examined 28 children and teens who developed long-lasting symptoms after COVID-19 infection. The researchers found that most patients had allergies and unusually high levels of immune proteins called IgE, IgG3, and IgG4. About three in ten patients also met criteria for ME/CFS, experiencing severe fatigue, breathing problems, and post-exertional malaise (feeling worse after activity). Most patients gradually improved over about a year, though some took longer to recover.

Immune System

E3 PreliminaryMechanismPEM requiredObservational

Sex-Dependent Transcriptional Changes in Response to Stress in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Project.

Gamer, Jackson, Van Booven, Derek J, Zarnowski, Oskar et al.·International journal of molecular sciences·2023

This study looked at how genes behave differently in men and women with ME/CFS when their bodies are stressed by exercise. Researchers tested blood samples from 33 ME/CFS patients and 34 healthy people before, during, and after exercise. They found that men and women with ME/CFS showed different patterns of gene activity in response to exercise—men's immune systems showed more dramatic changes, while women's genes related to stress response and virus handling showed bigger changes.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

The Long Road of Long COVID: Specific Considerations for the Allergist/Immunologist.

Bellanti, Joseph A, Novak, Peter, Faitelson, Yoram et al.·The journal of allergy and clinical immunology. In practice·2023

Long COVID is a condition that develops after a COVID-19 infection and can cause symptoms affecting many parts of the body, including heart problems, blood clots, fatigue, and autoimmune issues. This review examines what causes Long COVID and which patients are most at risk, noting that certain groups like Hispanic and Latino communities face higher rates. The authors highlight that while vaccines help prevent severe acute COVID, we still need more research to understand how they affect Long COVID development and progression.

Immune System

E3 PreliminaryMechanismPEM unclearMechanistic

A Proposed New Model to Explain the Role of Low Dose Non-DNA Targeted Radiation Exposure in Chronic Fatigue and Immune Dysfunction Syndrome.

Cocchetto, Alan, Seymour, Colin, Mothersill, Carmel·International journal of molecular sciences·2023

This study proposes a theory about how radiation exposure might trigger ME/CFS in some patients. The authors suggest that low-level radiation causes a chain reaction in the body involving free radicals (damaging molecules) and immune dysfunction, possibly linked to skin and blood cell problems. They reviewed evidence from people exposed to radiation (like after Chernobyl) who developed ME/CFS symptoms, to build a biological model explaining how this might happen.

Immune System

E3 PreliminaryMechanismPEM unclearMechanistic

Altered TRPM7-Dependent Calcium Influx in Natural Killer Cells of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients.

Du Preez, Stanley, Eaton-Fitch, Natalie, Smith, Peter K et al.·Biomolecules·2023

This study looked at how calcium moves into immune cells called NK cells in ME/CFS patients compared to healthy people. Researchers found that calcium enters these cells differently in ME/CFS patients—it flows in more slowly when activated but responds more strongly when blocked. This suggests a problem with a specific calcium channel called TRPM7 that may be involved in why NK cells don't work properly in ME/CFS.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Mitochondria: It is all about energy.

Casanova, Amaloha, Wevers, Anne, Navarro-Ledesma, Santiago et al.·Frontiers in physiology·2023

This review explains that mitochondria—the energy-producing structures in our cells—do much more than just make energy. They also help control sleep-wake cycles, interact with gut bacteria, and regulate the immune system. When mitochondria don't work properly, it may contribute to several diseases including ME/CFS, and the authors suggest that specific lifestyle and physiological strategies might help restore mitochondrial health.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Whole-body cryotherapy as a treatment for chronic medical conditions?

Tabisz, Hanna, Modlinska, Aleksandra, Kujawski, Sławomir et al.·British medical bulletin·2023

This review article examines whole-body cryotherapy (WBC)—exposing your entire body to very cold temperatures—as a possible treatment for various chronic conditions, including ME/CFS. The authors suggest that because WBC appears to reduce inflammation in the body, it might help conditions involving persistent inflammation. However, they emphasize that current research quality is low and that proper clinical trials are needed before we can know if WBC actually works.

Immune SystemNeuroinflammation

E3 PreliminaryMechanismPEM unclearCross-Sectional

Investigating Antibody Reactivity to the Intestinal Microbiome in Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Feasibility Study.

Seton, Katharine A, Defernez, Marianne, Telatin, Andrea et al.·International journal of molecular sciences·2023

This study explored whether ME/CFS might be caused by a leaky gut that allows bacteria to escape into the bloodstream, triggering an abnormal immune response. Researchers compared antibody levels and immune reactions to gut bacteria in severely ill ME/CFS patients and healthy household members. They found that ME/CFS patients showed reduced immune responses to their gut bacteria, which was unexpected and suggests the immune system may not be working properly in ME/CFS.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

The viral origin of myalgic encephalomyelitis/chronic fatigue syndrome.

Hanson, Maureen R·PLoS pathogens·2023

This review examines the evidence that viral infections may trigger or contribute to ME/CFS. Researchers looked at how viruses could potentially cause the long-lasting fatigue, pain, and other symptoms that define this condition. The study explores possible mechanisms by which a viral infection might set off a chain of events leading to ME/CFS.

Immune System

E3 PreliminaryCohortPEM unclearCross-Sectional

Autoantibody Correlation Signatures in Fibromyalgia and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Association with Symptom Severity.

Ryabkova, Varvara A, Gavrilova, Natalia Y, Poletaeva, Alina A et al.·Biomedicines·2023

This study looked at immune system antibodies in people with ME/CFS, particularly those who also have fibromyalgia. Researchers measured 33 different types of natural antibodies in patients' blood and found that people with ME/CFS had unusual patterns of these antibodies, especially ones targeting GABA receptors in the brain. While the overall antibody levels didn't always differ from healthy controls, the way these antibodies related to each other was different, and certain patterns correlated with fatigue, pain, and mood symptoms.

Immune System

E3 PreliminaryMechanismPEM unclearObservational

Causal Effects between Gut Microbiome and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Two-Sample Mendelian Randomization Study.

He, Gang, Cao, Yu, Ma, Honghao et al.·Frontiers in microbiology·2023

This study used genetic analysis to investigate whether changes in gut bacteria might actually cause ME/CFS, rather than just being associated with it. Researchers found that two types of bacteria—Paraprevotella and Ruminococcaceae_UCG_014—appear to increase the risk of developing ME/CFS. These findings suggest that gut bacteria may play a role in how ME/CFS develops.

Immune SystemGut Microbiome

E3 PreliminaryMechanismPEM unclearMechanistic

Serum from Myalgic encephalomyelitis/chronic fatigue syndrome patients causes loss of coherence in cellular circadian rhythms.

Wei, Heather, Adelsheim, Zoe, Fischer, Rita et al.·Journal of neuroimmunology·2023

This study found that blood serum from ME/CFS patients disrupts the internal 24-hour biological clock (circadian rhythm) in cells grown in the laboratory, compared to serum from healthy people. The disruption was linked to how severe patients' sleep problems were. While a protein called TGF-beta contributed to some rhythm changes, it didn't fully explain the effect, suggesting other unknown factors in ME/CFS patients' blood are responsible.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Astragalus polysaccharide ameliorated complex factor-induced chronic fatigue syndrome by modulating the gut microbiota and metabolites in mice.

Wei, Xintong, Xin, Jiayun, Chen, Wei et al.·Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2023

Researchers gave a compound called astragalus polysaccharide (APS) to mice bred to model chronic fatigue syndrome and observed changes in their gut bacteria, inflammatory markers, and fatigue-related behaviors. One proposed mechanism involves the gut producing more short-chain fatty acids (particularly butyrate), which in the lab showed antioxidant and anti-inflammatory effects on nerve cells. However, this is early-stage research in animals; whether these findings apply to human ME/CFS remains unclear.

Immune SystemGut Microbiome

E3 PreliminaryMechanismPEM requiredMechanistic

Post-COVID exercise intolerance is associated with capillary alterations and immune dysregulations in skeletal muscles.

Aschman, Tom, Wyler, Emanuel, Baum, Oliver et al.·Acta neuropathologica communications·2023

Researchers examined muscle tissue from people with long COVID who experience fatigue and worsening symptoms after activity. They found that these patients had fewer blood vessels in their muscles, thicker vessel walls, and signs of immune cells that might have been triggered by the initial infection. These physical changes in the muscle's blood supply could explain why exercise makes their symptoms worse.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

αβ and γδ T-cell responses to Epstein-Barr Virus: insights in immunocompetence, immune failure and therapeutic augmentation in transplant patients.

Eiz-Vesper, Britta, Ravens, Sarina, Maecker-Kolhoff, Britta·Current opinion in immunology·2023

This review examines how the immune system responds to Epstein-Barr Virus (EBV), a common virus associated with various illnesses including mononucleosis and, reportedly, chronic fatigue syndrome. The authors survey recent research on how immune cells control EBV, particularly in transplant patients whose immune systems are weakened by medication. While the review discusses potential therapeutic approaches to strengthen immune responses against EBV, these remain largely experimental and preliminary.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

The Role of Neuro-Immune Interaction in Chronic Pain Conditions; Functional Somatic Syndrome, Neurogenic Inflammation, and Peripheral Neuropathy.

Meade, Elaine, Garvey, Mary·International journal of molecular sciences·2022

This review article examines how the nervous and immune systems interact to cause chronic pain and fatigue in conditions like ME/CFS, fibromyalgia, and IBS. The authors explain that childhood trauma and ongoing stress can permanently change how the body's stress response system works, leading to long-term symptoms. They discuss how these systems become dysregulated and contribute to the wide range of symptoms people with these conditions experience.

Immune SystemNeuroinflammation

E3 PreliminaryMechanismPEM unclearMechanistic

Transient receptor potential melastatin 3 dysfunction in post COVID-19 condition and myalgic encephalomyelitis/chronic fatigue syndrome patients.

Sasso, Etianne Martini, Muraki, Katsuhiko, Eaton-Fitch, Natalie et al.·Molecular medicine (Cambridge, Mass.)·2022

This study examined a specific ion channel called TRPM3 in immune cells from patients with ME/CFS and long COVID, comparing them to healthy people. Researchers found that both ME/CFS and long COVID patients had similar problems with how this ion channel functions. The findings suggest that broken ion channels might be part of why these conditions cause long-lasting fatigue and other symptoms.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

The autonomic aspects of the post-COVID19 syndrome.

Dotan, Arad, David, Paula, Arnheim, Dana et al.·Autoimmunity reviews·2022

After COVID-19 infection, many people experience long-lasting symptoms similar to ME/CFS, including fatigue, brain fog, and mood problems. Recent research suggests the immune system may attack nerve cells that control heart rate, blood pressure, and other automatic body functions, rather than just the virus itself. The authors propose that exercise therapy might be safer and more helpful than immunosuppressive drugs for treating these lingering post-COVID symptoms.

Immune System

E3 PreliminaryMechanismPEM requiredMechanistic

Exosome-associated mitochondrial DNA from patients with myalgic encephalomyelitis/chronic fatigue syndrome stimulates human microglia to release IL-1β.

Tsilioni, Irene, Natelson, Benjamin, Theoharides, Theoharis C·The European journal of neuroscience·2022

This study found that after exercise, patients with ME/CFS have more pieces of DNA from their mitochondria (the energy-producing parts of cells) floating in their blood inside tiny particles called exosomes. When researchers tested these exosomes on immune cells in the lab, they triggered the release of IL-1β, a chemical that causes inflammation in the brain. This suggests that exercise might trigger a chain reaction involving these DNA-carrying particles that could contribute to ME/CFS symptoms.

Immune SystemNeuroinflammation

E3 PreliminaryMechanismPEM unclearMechanistic

Impaired TRPM3-dependent calcium influx and restoration using Naltrexone in natural killer cells of myalgic encephalomyelitis/chronic fatigue syndrome patients.

Eaton-Fitch, Natalie, Du Preez, Stanley, Cabanas, Hélène et al.·Journal of translational medicine·2022

Researchers examined a calcium-channel protein called TRPM3 in immune cells called natural killer cells from ME/CFS patients and compared them with healthy controls. They observed that calcium movement through TRPM3 was reduced in ME/CFS patients at baseline. When they treated isolated cells overnight with a drug called naltrexone, calcium movement improved in the ME/CFS patients' cells. These are early findings from a laboratory study and do not yet establish whether naltrexone would produce the same effect in people taking the drug.

Immune System

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Atopy and Elevation of IgE, IgG3, and IgG4 May Be Risk Factors for Post COVID-19 Condition in Children and Adolescents.

Sex-Dependent Transcriptional Changes in Response to Stress in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Project.

The Long Road of Long COVID: Specific Considerations for the Allergist/Immunologist.

A Proposed New Model to Explain the Role of Low Dose Non-DNA Targeted Radiation Exposure in Chronic Fatigue and Immune Dysfunction Syndrome.

Altered TRPM7-Dependent Calcium Influx in Natural Killer Cells of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients.

Mitochondria: It is all about energy.

Whole-body cryotherapy as a treatment for chronic medical conditions?

Investigating Antibody Reactivity to the Intestinal Microbiome in Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Feasibility Study.

The viral origin of myalgic encephalomyelitis/chronic fatigue syndrome.

Autoantibody Correlation Signatures in Fibromyalgia and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Association with Symptom Severity.

Causal Effects between Gut Microbiome and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Two-Sample Mendelian Randomization Study.

Serum from Myalgic encephalomyelitis/chronic fatigue syndrome patients causes loss of coherence in cellular circadian rhythms.

Astragalus polysaccharide ameliorated complex factor-induced chronic fatigue syndrome by modulating the gut microbiota and metabolites in mice.

Post-COVID exercise intolerance is associated with capillary alterations and immune dysregulations in skeletal muscles.

αβ and γδ T-cell responses to Epstein-Barr Virus: insights in immunocompetence, immune failure and therapeutic augmentation in transplant patients.

The Role of Neuro-Immune Interaction in Chronic Pain Conditions; Functional Somatic Syndrome, Neurogenic Inflammation, and Peripheral Neuropathy.

Transient receptor potential melastatin 3 dysfunction in post COVID-19 condition and myalgic encephalomyelitis/chronic fatigue syndrome patients.

The autonomic aspects of the post-COVID19 syndrome.

Exosome-associated mitochondrial DNA from patients with myalgic encephalomyelitis/chronic fatigue syndrome stimulates human microglia to release IL-1β.

Impaired TRPM3-dependent calcium influx and restoration using Naltrexone in natural killer cells of myalgic encephalomyelitis/chronic fatigue syndrome patients.

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