E1 ReplicatedTrialPEM not requiredRCT
Adaptive pacing, cognitive behaviour therapy, graded exercise, and specialist medical care for chronic fatigue syndrome: a cost-effectiveness analysis.
McCrone, Paul, Sharpe, Michael, Chalder, Trudie et al.·PloS one·2012
This study compared the cost and benefit of four different treatments for ME/CFS: specialist medical care alone, cognitive behaviour therapy (CBT), graded exercise therapy (GET), and adaptive pacing therapy (APT). Researchers found that CBT was the most cost-effective option, meaning it provided good health improvements relative to its cost, while APT was the least cost-effective. The study looked at both healthcare costs and broader societal costs like lost work time.