ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

321 studies

21–40 of 321 studies

Balneotherapy for the treatment of post-COVID syndrome: a randomized controlled trial.

Ovejero, Diana, Ribes, Anna, Villar-García, Judit et al.·BMC complementary medicine and therapies·2025

Researchers tested whether balneotherapy (therapeutic bathing and aquatic exercises) could help people with long COVID symptoms. Ninety-eight adults with long COVID participated—half received 12 sessions of balneotherapy over one month, while the other half did not. The treatment group showed improvements in sleep quality, anxiety, pain, and fatigue compared to the control group, though some people experienced temporary worsening of fatigue during early sessions.

Post-Exertional Malaise

E1 ReplicatedTrialPEM unclearObservational

Integrative multimodal treatment approach for patients suffering from Post-COVID syndrome: a study based on qualitative interviews with individuals participating in an 11-week day clinic program.

Uecker, Christine, Schlee, Christoph, Utz, Sandra et al.·Frontiers in public health·2025

This study looked at whether a combined treatment program could help people with Post-COVID syndrome (including severe cases similar to ME/CFS). Twenty patients participated in an 11-week day clinic program that used multiple approaches like physical therapy, nutrition, stress management, and mental health support. Patients reported feeling significantly better after the program, with improvements in fatigue, pain, and their ability to cope with daily activities.

E1 ReplicatedCohortPEM unclearLongitudinal

Six-year follow-up of participants in two clinical trials of rituximab or cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Rekeland, Ingrid G, Sørland, Kari, Neteland, Lisbeth Lykke et al.·PloS one·2024

This study followed patients with ME/CFS for six years after they received either rituximab (an antibody treatment), cyclophosphamide (a chemotherapy drug), or placebo in two earlier clinical trials. The researchers tracked how much the patients could do in their daily lives using standard questionnaires. Cyclophosphamide showed the most improvement, with 44% of those patients reaching good functional levels after six years, but the rituximab and placebo groups showed smaller benefits.

E1 ReplicatedTrialPEM unclearRCT

The effects of 3-month supplementation with synbiotic on patient-reported outcomes, exercise tolerance, and brain and muscle metabolism in adult patients with post-COVID-19 chronic fatigue syndrome (STOP-FATIGUE): a randomized Placebo-controlled clinical trial.

Ranisavljev, Marijana, Stajer, Valdemar, Todorovic, Nikola et al.·European journal of nutrition·2024

This study tested whether a special mixture of beneficial gut bacteria (probiotics) plus fiber and zinc could help people with post-COVID chronic fatigue syndrome (ME/CFS). Over three months, 26 patients took either the synbiotic mixture or a placebo, and researchers measured their fatigue, exercise recovery, and brain/muscle chemistry. The synbiotic group experienced better recovery after exercise and showed improvements in brain chemistry compared to the placebo group, though both groups felt less general fatigue.

Post-Exertional Malaise

E1 ReplicatedTrialPEM not requiredRCT

Acupoint massage at Shenque (CV 8) for chronic fatigue syndrome: a randomized controlled trial.

Li, Zhijun, Ji, Rong, Yan, Chaoqun et al.·Zhongguo zhen jiu = Chinese acupuncture & moxibustion·2024

Researchers tested whether massaging a specific acupuncture point called Shenque (located on the abdomen) could help people with chronic fatigue syndrome. Patients in the treatment group received 10-minute massages three times a week for four weeks, while the control group received no treatment. The treatment group showed meaningful improvements in fatigue and sleep quality compared to the control group.

Sleep

E1 ReplicatedTrialPEM unclearRCT

Graded exercise therapy compared to activity management for paediatric chronic fatigue syndrome/myalgic encephalomyelitis: pragmatic randomized controlled trial.

Gaunt, Daisy M, Brigden, Amberly, Harris, Shaun R S et al.·European journal of pediatrics·2024

This study compared two types of treatment for children with ME/CFS: graded exercise therapy (gradually increasing physical activity) and activity management (focusing on managing daily activities at school, home, and socially). After 6 and 12 months, both treatments showed only small improvements, and there was no clear difference between them. In fact, children receiving exercise therapy showed a slightly higher risk of getting worse.

E1 ReplicatedTrialPEM not requiredRCT

Effects of Qiye Shen'an Pian Combined with Glutamate and Vitamin B1 on Fatigue State, Immune Function and Quality of Life in Patients with Chronic Fatigue Syndrome.

Liu, Jun, Liao, Junfeng, Lin, Fan et al.·Alternative therapies in health and medicine·2024

Researchers tested whether a traditional Chinese herbal supplement (Qiye Shen'an Pian) combined with glutathione and vitamin B1 could help ME/CFS patients feel less tired and improve their immune system. Over 8 weeks, patients receiving the herbal supplement along with the standard treatment showed greater improvements in fatigue levels, immune markers, and overall quality of life compared to those receiving only the standard treatment.

Immune System

E1 ReplicatedTrialPEM unclearRCT

Lower hair cortisol concentration in adolescent and young adult patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Q-Fever Fatigue Syndrome compared to controls.

Vroegindeweij, Anouk, Eijkelkamp, Niels, van den Berg, Sjoerd A A et al.·Psychoneuroendocrinology·2024

This study looked at cortisol (a stress hormone) levels in hair samples from young people with ME/CFS and other fatigue conditions. Researchers found that people with ME/CFS and Q-Fever Fatigue Syndrome had lower cortisol levels in their hair compared to healthy people, suggesting a long-term difference in how their bodies handle this hormone. Interestingly, baseline cortisol levels did not predict whether patients would improve with lifestyle and dietary changes.

Endocrine Disruption

E1 ReplicatedTrialPEM not requiredRCT

Online acceptance and commitment therapy (iACT) for adults with persistent physical symptoms - 3-month follow-up study of a randomized controlled trial.

Lappalainen, Päivi, Keinonen, Katariina, Lappalainen, Raimo et al.·Journal of psychosomatic research·2024

This study tested whether an online therapy program based on acceptance and commitment therapy (ACT) could help adults with persistent physical symptoms like chronic fatigue and environmental sensitivities. Adults receiving the 14-week online program combined with their usual medical care showed greater improvements in symptom severity, depression, and anxiety compared to those receiving usual care alone, with benefits lasting at least 3 months.

E1 ReplicatedTrialPEM not requiredRCT

Implication of cognitive-behavioral stress management on anxiety, depression, and quality of life in acute myocardial infarction patients after percutaneous coronary intervention: a multicenter, randomized, controlled study.

Chen, Biqun, Wen, Juanling, You, Deyi et al.·Irish journal of medical science·2024

This study tested whether a type of talk therapy called cognitive-behavioral stress management (CBSM) could help heart attack patients feel less anxious and depressed after receiving a stent procedure. Over 6 months, patients who received CBSM weekly for 12 weeks showed improvements in anxiety, depression, and overall quality of life compared to those receiving standard care. However, the therapy did not reduce the risk of future heart problems.

E1 ReplicatedTrialPEM not requiredRCT

Impact of combined plant extracts on long COVID: An exploratory randomized controlled trial.

Lukkunaprasit, Thitiya, Satapornpong, Patompong, Kulchanawichien, Pongsiri et al.·Complementary therapies in medicine·2024

Researchers tested whether a supplement made from five plant extracts could help people with long COVID feel better. Over 7 days, people taking the supplement reported feeling less fatigued and had fewer severe symptoms like post-exertional malaise (worsening after activity) compared to those taking a placebo. The supplement was generally safe, though the study was small and longer research is needed to confirm these results.

Post-Exertional Malaise

E1 ReplicatedTrialPEM not requiredRCT

Comparison of cognitive behaviour therapy versus activity management, both delivered remotely, to treat paediatric chronic fatigue syndrome/myalgic encephalomyelitis: the UK FITNET-NHS RCT.

Crawley, Esther, Anderson, Emma, Cochrane, Madeleine et al.·Health technology assessment (Winchester, England)·2024

This study compared two online treatments for teenagers with ME/CFS: a cognitive behavioural therapy programme called FITNET-NHS and activity management delivered by video calls. After 6 months, teenagers using FITNET-NHS showed better improvements in physical function and attended about half a day more school per week than those receiving activity management. However, FITNET-NHS was more expensive, and by 12 months both groups had improved similarly, making it unclear whether the extra cost was worth the temporary benefit.

E1 ReplicatedTrialPEM unclearRCT

RESTORE ME: a RCT of oxaloacetate for improving fatigue in patients with myalgic encephalomyelitis/chronic fatigue syndrome.

Cash, Alan, Vernon, Suzanne D, Rond, Candace et al.·Frontiers in neurology·2024

This study tested whether a supplement called oxaloacetate could help reduce fatigue in ME/CFS patients. Eighty-two people with ME/CFS took either 2,000 mg of oxaloacetate or a placebo daily for three months. The oxaloacetate group experienced a significant 25% reduction in fatigue, while the placebo group only improved by 10%, and the supplement was well tolerated with no safety concerns.

Energy Metabolism

E1 ReplicatedTrialPEM requiredRCT

Effects of a symptom-titrated exercise program on fatigue and quality of life in people with post-COVID condition - a randomized controlled trial.

Barz, Andreas, Berger, Joshua, Speicher, Marco et al.·Scientific reports·2024

This study tested whether a personalized exercise program that adjusts based on daily fatigue levels helps people with post-COVID condition. Over 10 weeks, 118 participants did exercise at commercial fitness facilities while a qualified trainer adjusted the intensity based on how they felt that day. The program significantly improved fatigue, quality of life, and physical strength without making symptoms worse.

Post-Exertional Malaise

E1 ReplicatedTrialPEM unclearRCT

Effectiveness of an online multicomponent program (FATIGUEWALK) for chronic fatigue syndrome: A randomized controlled trial.

Serrat, Mayte, Navarrete, Jaime, Ferrés, Sònia et al.·Health psychology : official journal of the Division of Health Psychology, American Psychological Association·2024

Researchers tested an online 12-week program called FATIGUEWALK that combines education about pain and fatigue, gentle exercise, cognitive techniques, and mindfulness training for people with ME/CFS. Compared to people who only received standard care, those who completed FATIGUEWALK showed meaningful improvements in fatigue, pain, mood, and daily functioning. About 1 in 5 participants improved with the program who wouldn't have with standard care alone.

E1 ReplicatedTrialPEM requiredRCT

Exercise does not cause post-exertional malaise in Veterans with Gulf War Illness: A randomized, controlled, dose-response, crossover study.

Boruch, Alexander E, Barhorst, Ellen E, Rayne, Tessa J et al.·Brain, behavior, and immunity·2024

This study tested whether exercise of different intensities causes post-exertional malaise (PEM)—a worsening of symptoms after physical activity—in veterans with Gulf War Illness, a condition similar to ME/CFS. Forty participants did light, moderate, or vigorous cycling for 20 minutes, or simply rested, while researchers measured their symptoms, pain sensitivity, thinking ability, and blood markers before and after. The study found that exercise did not cause greater symptom worsening or other problems than rest, even at higher intensities.

Post-Exertional Malaise

E1 ReplicatedTrialPEM not requiredRCT

Sijunzi decoction, a classical Chinese herbal formula, improves fatigue symptoms with changes in gut microbiota in chronic fatigue syndrome: A randomized, double-blind, placebo-controlled, multi-center clinical trial.

Dai, Liang, Liu, Zhidong, Zhou, Wenjuan et al.·Phytomedicine : international journal of phytotherapy and phytopharmacology·2024

This study tested whether Sijunzi decoction, a traditional Chinese herbal formula, could reduce fatigue in ME/CFS patients. Over 100 people with ME/CFS took either the herbal formula or a placebo for 2 months. The herbal treatment group showed slightly more improvement in fatigue symptoms and overall health than the placebo group, and the improvement may be linked to changes in gut bacteria.

Gut Microbiome

E1 ReplicatedTrialPEM requiredRCT

Videoconference-delivered group Cognitive Behavioral Stress Management for ME/CFS patients who present with severe PEM: A randomized controlled trial.

May, Marcella, Milrad, Sara F, Perdomo, Dolores M et al.·Fatigue : biomedicine, health & behavior·2024

This study tested whether a stress management program delivered by video could help ME/CFS patients who experience severe post-exertional malaise (PEM)—the worsening of symptoms after activity. Patients either received 10 weeks of cognitive behavioral stress management training or health information. For patients with severe PEM, the stress management program led to meaningful improvements in symptom frequency, symptom intensity, and fatigue-related problems, suggesting that managing stress may help reduce PEM severity.

Post-Exertional Malaise

E1 ReplicatedTrialPEM not requiredRCT

Efficacy of aquatic vs land-based therapy for pain management in women with fibromyalgia: a randomised controlled trial.

Rivas Neira, S, Pasqual Marques, A, Fernández Cervantes, R et al.·Physiotherapy·2024

This study compared two types of exercise therapy for women with fibromyalgia: exercising in a pool (aquatic therapy) versus exercising on land. Both groups did 60-minute exercise sessions three times a week for 12 weeks. Six weeks after the program ended, women who did aquatic therapy reported less pain and better sleep quality than those who exercised on land, suggesting that water-based exercise may be particularly helpful for fibromyalgia.

Pain and SensitizationSleep

E1 ReplicatedTrialPEM not requiredRCT

Herbal extract (Cervus elaphus Linnaeus, Angelica gigas Nakai, and Astragalus membranaceus Bunge) ameliorates chronic fatigue: A randomized, placebo-controlled, double-blind trial.

Ahn, SoYoung, Jamrasi, Parivash, Lim, Byunggul et al.·Integrative medicine research·2024

This study tested whether a herbal supplement made from deer antler, angelica root, and astragalus could reduce fatigue in people with chronic fatigue syndrome. Over 8 weeks, 80 patients took either the herbal mixture or a placebo, and researchers measured their fatigue levels and exercise capacity. The herbal supplement group showed meaningful improvements in fatigue symptoms and could exercise longer before exhaustion compared to the placebo group.

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Balneotherapy for the treatment of post-COVID syndrome: a randomized controlled trial.

Integrative multimodal treatment approach for patients suffering from Post-COVID syndrome: a study based on qualitative interviews with individuals participating in an 11-week day clinic program.

Six-year follow-up of participants in two clinical trials of rituximab or cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

The effects of 3-month supplementation with synbiotic on patient-reported outcomes, exercise tolerance, and brain and muscle metabolism in adult patients with post-COVID-19 chronic fatigue syndrome (STOP-FATIGUE): a randomized Placebo-controlled clinical trial.

Acupoint massage at Shenque (CV 8) for chronic fatigue syndrome: a randomized controlled trial.

Graded exercise therapy compared to activity management for paediatric chronic fatigue syndrome/myalgic encephalomyelitis: pragmatic randomized controlled trial.

Effects of Qiye Shen'an Pian Combined with Glutamate and Vitamin B1 on Fatigue State, Immune Function and Quality of Life in Patients with Chronic Fatigue Syndrome.

Lower hair cortisol concentration in adolescent and young adult patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Q-Fever Fatigue Syndrome compared to controls.

Online acceptance and commitment therapy (iACT) for adults with persistent physical symptoms - 3-month follow-up study of a randomized controlled trial.

Implication of cognitive-behavioral stress management on anxiety, depression, and quality of life in acute myocardial infarction patients after percutaneous coronary intervention: a multicenter, randomized, controlled study.

Impact of combined plant extracts on long COVID: An exploratory randomized controlled trial.

Comparison of cognitive behaviour therapy versus activity management, both delivered remotely, to treat paediatric chronic fatigue syndrome/myalgic encephalomyelitis: the UK FITNET-NHS RCT.

RESTORE ME: a RCT of oxaloacetate for improving fatigue in patients with myalgic encephalomyelitis/chronic fatigue syndrome.

Effects of a symptom-titrated exercise program on fatigue and quality of life in people with post-COVID condition - a randomized controlled trial.

Effectiveness of an online multicomponent program (FATIGUEWALK) for chronic fatigue syndrome: A randomized controlled trial.

Exercise does not cause post-exertional malaise in Veterans with Gulf War Illness: A randomized, controlled, dose-response, crossover study.

Sijunzi decoction, a classical Chinese herbal formula, improves fatigue symptoms with changes in gut microbiota in chronic fatigue syndrome: A randomized, double-blind, placebo-controlled, multi-center clinical trial.

Videoconference-delivered group Cognitive Behavioral Stress Management for ME/CFS patients who present with severe PEM: A randomized controlled trial.

Efficacy of aquatic vs land-based therapy for pain management in women with fibromyalgia: a randomised controlled trial.

Herbal extract (Cervus elaphus Linnaeus, Angelica gigas Nakai, and Astragalus membranaceus Bunge) ameliorates chronic fatigue: A randomized, placebo-controlled, double-blind trial.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research

Evidence Atlas

Evidence browser

Balneotherapy for the treatment of post-COVID syndrome: a randomized controlled trial.

Integrative multimodal treatment approach for patients suffering from Post-COVID syndrome: a study based on qualitative interviews with individuals participating in an 11-week day clinic program.

Six-year follow-up of participants in two clinical trials of rituximab or cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

The effects of 3-month supplementation with synbiotic on patient-reported outcomes, exercise tolerance, and brain and muscle metabolism in adult patients with post-COVID-19 chronic fatigue syndrome (STOP-FATIGUE): a randomized Placebo-controlled clinical trial.

Acupoint massage at Shenque (CV 8) for chronic fatigue syndrome: a randomized controlled trial.

Graded exercise therapy compared to activity management for paediatric chronic fatigue syndrome/myalgic encephalomyelitis: pragmatic randomized controlled trial.

Effects of Qiye Shen'an Pian Combined with Glutamate and Vitamin B1 on Fatigue State, Immune Function and Quality of Life in Patients with Chronic Fatigue Syndrome.

Lower hair cortisol concentration in adolescent and young adult patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Q-Fever Fatigue Syndrome compared to controls.

Online acceptance and commitment therapy (iACT) for adults with persistent physical symptoms - 3-month follow-up study of a randomized controlled trial.

Implication of cognitive-behavioral stress management on anxiety, depression, and quality of life in acute myocardial infarction patients after percutaneous coronary intervention: a multicenter, randomized, controlled study.

Impact of combined plant extracts on long COVID: An exploratory randomized controlled trial.

Comparison of cognitive behaviour therapy versus activity management, both delivered remotely, to treat paediatric chronic fatigue syndrome/myalgic encephalomyelitis: the UK FITNET-NHS RCT.

RESTORE ME: a RCT of oxaloacetate for improving fatigue in patients with myalgic encephalomyelitis/chronic fatigue syndrome.

Effects of a symptom-titrated exercise program on fatigue and quality of life in people with post-COVID condition - a randomized controlled trial.

Effectiveness of an online multicomponent program (FATIGUEWALK) for chronic fatigue syndrome: A randomized controlled trial.

Exercise does not cause post-exertional malaise in Veterans with Gulf War Illness: A randomized, controlled, dose-response, crossover study.

Sijunzi decoction, a classical Chinese herbal formula, improves fatigue symptoms with changes in gut microbiota in chronic fatigue syndrome: A randomized, double-blind, placebo-controlled, multi-center clinical trial.

Videoconference-delivered group Cognitive Behavioral Stress Management for ME/CFS patients who present with severe PEM: A randomized controlled trial.

Efficacy of aquatic vs land-based therapy for pain management in women with fibromyalgia: a randomised controlled trial.

Herbal extract (Cervus elaphus Linnaeus, Angelica gigas Nakai, and Astragalus membranaceus Bunge) ameliorates chronic fatigue: A randomized, placebo-controlled, double-blind trial.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research

Integrative multimodal treatment approach for patients suffering from Post-COVID syndrome: a study based on qualitative interviews with individuals participating in an 11-week day clinic program.