ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1601–1620 of 2,423 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

[On the important role of Siguan points in treatment of chronic fatigue syndrome].

Wang, Jing-jing, Meng, Hong, Cui, Cheng-bin et al.·Zhongguo zhen jiu = Chinese acupuncture & moxibustion·2006

This study examined whether a traditional Chinese medicine acupuncture technique called Siguan points might help treat chronic fatigue syndrome (ME/CFS). The researchers reviewed existing literature on this acupuncture method and concluded that using Siguan points as the main treatment approach showed promise for improving ME/CFS symptoms.

Interventions

E3 PreliminaryReviewPEM not requiredReview-Narrative

Protective efficacy, immunotherapeutic potential, and safety of hepatitis B vaccines.

Zuckerman, Jane N·Journal of medical virology·2006

This review examines hepatitis B vaccines, which are widely used and have an excellent safety record across over 150 countries. The authors specifically addressed concerns about whether these vaccines cause chronic fatigue syndrome, and found no evidence of such a connection. The study looked at how well these vaccines work, why some people don't respond to them, and potential new ways to use them to treat hepatitis B infection.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Conceptual issues in undifferentiated somatoform disorder and chronic fatigue syndrome.

van Staden, Werdie C W·Current opinion in psychiatry·2006

This paper examines why it can be difficult to distinguish between two conditions that both cause severe tiredness: undifferentiated somatoform disorder (a condition where physical symptoms occur without clear medical causes) and ME/CFS. The author argues that a key difference may be how patients experience their fatigue—some describe it as purely physical rather than mental—and that this distinction has not been properly studied or recognized in ME/CFS research.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome--exercise and physical activity].

Greenberg, Shai, Frid, Mordechai·Harefuah·2006

People with ME/CFS often feel extremely tired and struggle with physical activity, experiencing worsening symptoms even after light exercise. This review found that ME/CFS patients typically have lower fitness levels, their hearts work harder during normal activity, and they take longer to recover than healthy people. The good news is that carefully guided exercise programs appear to be the most helpful treatment for improving energy levels, physical function, and daily life activities.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Highlights from 5th International Conference on HHV-6 and -7.

Komaroff, Anthony L, Jacobson, Steven, Ablashi, Dharam V et al.·Herpes : the journal of the IHMF·2006

Scientists at an international conference discussed new tests to detect two common viruses (HHV-6 and HHV-7) in the body and whether they might trigger nervous system diseases. These viruses can infect brain cells, and researchers think they may play a role in conditions like chronic fatigue syndrome, along with multiple sclerosis and other neurological problems. Better tests are being developed to tell if someone has an active infection or just carries the virus dormant.

E3 PreliminaryReviewPEM unclearReview-Narrative

[The chronic fatigue syndrome and its diagnosis in internal medicine].

Barbado Hernández, F J, Gómez Cerezo, J, López Rodríguez, M et al.·Anales de medicina interna (Madrid, Spain : 1984)·2006

This article reviews how chronic fatigue syndrome (ME/CFS) is diagnosed and understood within internal medicine practice. The authors discuss the clinical features, diagnostic criteria, and challenges that doctors face when identifying ME/CFS in patients. The paper helps physicians recognize and properly diagnose this condition in their everyday practice.

Diagnostics

E3 PreliminaryBehavioralPEM unclearLongitudinal

Toward a trajectory of identity reconstruction in chronic fatigue syndrome/myalgic encephalomyelitis: a longitudinal qualitative study.

Whitehead, Lisa·International journal of nursing studies·2006

This study followed 17 people with ME/CFS over time to understand how the illness changed how they saw themselves. The researchers found that people's sense of identity shifted depending on how sick they were and how others treated them. Over the long term, most people developed ways to cope that helped them build a more stable sense of who they were, even while managing their illness.

E3 PreliminaryMechanismPEM not requiredMechanistic

Brain cytokines and the 5-HT system during poly I:C-induced fatigue.

Katafuchi, Toshihiko, Kondo, Tetsuya, Take, Sachiko et al.·Annals of the New York Academy of Sciences·2006

This study investigated how the brain's immune system might cause fatigue by looking at what happens when rats are exposed to a viral-like trigger. Researchers found that certain immune molecules in the brain (interferons) increased while a key fatigue-related brain chemical (serotonin) decreased. When they gave the rats a medication that boosted serotonin activity, the fatigue improved, suggesting that low serotonin in a specific brain region may play a role in fatigue.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome in cardiology neurohumoral changes].

Iasiukiavichene, L, Vasiliauskas, D·Kardiologiia·2006

This review examines why people with heart disease often experience severe fatigue and how the body's stress response system may be involved. The authors explain that chronic fatigue is a condition affecting the immune system, hormones, and nervous system, and can be triggered by stress, surgery, infections, or other illnesses. They suggest that measuring a stress hormone called cortisol could help doctors identify and treat fatigue in heart patients.

Endocrine Disruption

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The challenge of integrating disparate high-content data: epidemiological, clinical and laboratory data collected during an in-hospital study of chronic fatigue syndrome.

Vernon, Suzanne D, Reeves, William C·Pharmacogenomics·2006

Researchers invited people with ME/CFS, people with other unexplained fatigue illnesses, and healthy controls to stay in a hospital for 2 days. During the visit, they measured brain chemicals, nervous system function, immune markers, and gene activity. A team of 20 scientists from different fields worked together to find new ways to understand all this information and look for biological markers that might explain ME/CFS.

Sleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

Is human herpesvirus-6 a trigger for chronic fatigue syndrome?

Komaroff, Anthony L·Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2006

This study reviews evidence about whether a virus called human herpesvirus-6 (HHV-6) might cause ME/CFS. Researchers found that active HHV-6 infection appears more frequently in ME/CFS patients than in healthy people, and the virus may be connected to some of the nervous system and immune system problems seen in ME/CFS. However, not all ME/CFS patients test positive for active HHV-6, suggesting it may only trigger the illness in some people.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Identifying illness parameters in fatiguing syndromes using classical projection methods.

Broderick, Gordon, Craddock, R Cameron, Whistler, Toni et al.·Pharmacogenomics·2006

Researchers studied 111 women to find common patterns that distinguish ME/CFS patients from healthy controls by looking at both their symptoms and gene activity in blood cells. They used a statistical method to combine multiple pieces of information—like fatigue scores, quality of life measures, and which genes were active—rather than looking at single factors alone. The analysis identified key differences related to stress in cells, immune problems, and imbalanced minerals, particularly reflected in abnormal heart rate patterns during sleep.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Neuropsychiatric symptoms related to interferon alpha].

Małyszczak, Krzysztof, Inglot, Małgorzata, Pawłowski, Tomasz et al.·Psychiatria polska·2006

Interferon alpha, a medication used to treat hepatitis C and B, cancer, and other serious illnesses, commonly causes psychiatric and neurological side effects including depression, fatigue, anxiety, and cognitive problems in up to half of patients. These symptoms occur because interferon directly affects the brain and triggers a cascade of chemical changes, including alterations to serotonin and other neurotransmitters. The good news is that these symptoms can often be managed with antidepressants, therapy, and behavioral support.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Chronic fatigue syndrome is accompanied by an IgM-related immune response directed against neopitopes formed by oxidative or nitrosative damage to lipids and proteins.

Maes, Michael, Mihaylova, Ivana, Leunis, Jean-Claude·Neuro endocrinology letters·2006

This study found that people with ME/CFS have higher levels of immune antibodies (IgM) attacking damaged fats and proteins in their bodies. These antibodies target substances created when cells are damaged by oxidative stress—a harmful process where the body's natural defenses become imbalanced. The more severe someone's ME/CFS symptoms were, the higher their antibody levels tended to be.

BiomarkersImmune System

E3 PreliminaryBehavioralPEM not requiredObservational

Chronic Fatigue Syndrome: An Evaluation of a Community Based Management Programme for Adolescents and their Families.

Ashby, Bernadette, Wright, Barry, Jordan, Jo·Child and adolescent mental health·2006

This study looked at how a community-based treatment program helped young people with ME/CFS and their families. Researchers interviewed teenagers and parents about their experience with an approach that combined physical rehabilitation with attention to both body and mind. The families reported improvements across the key areas addressed, and most valued this collaborative treatment method.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome.

Nursing times·2006

This article provides an overview of chronic fatigue syndrome (ME/CFS) for nursing professionals. It covers the basic understanding of the condition, its impact on patients, and how healthcare providers can better support people living with ME/CFS.

E3 PreliminaryReviewPEM unclearReview-Narrative

Proton and 31-phosphorus neurospectroscopy in the study of membrane phospholipids and fatty acid intervention in schizophrenia, depression, chronic fatigue syndrome (myalgic encephalomyelitis) and dyslexia.

Puri, Basant K·International review of psychiatry (Abingdon, England)·2006

This study describes advanced brain imaging techniques that can measure specific chemicals in the brain without surgery. These techniques help researchers understand how the brain uses fats and other building blocks to maintain healthy cell membranes. The authors explain how these imaging methods could be applied to study brain chemistry in ME/CFS and other conditions.

Energy Metabolism

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Brief and distinct empirical sleepiness and fatigue scales.

Bailes, Sally, Libman, Eva, Baltzan, Marc et al.·Journal of psychosomatic research·2006

Doctors and patients often use the words 'sleepiness' and 'fatigue' interchangeably, but they actually describe different experiences. This study created two short, separate questionnaires—one to measure sleepiness (the urge to sleep) and one to measure fatigue (overall exhaustion)—by pulling items from existing popular fatigue and sleepiness scales. Testing these new scales on people with ME/CFS, narcolepsy, and healthy controls showed they measure distinct conditions that may respond to different treatments.

SleepDiagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Explanatory and pragmatic perspectives regarding idiopathic physical symptoms and related syndromes.

Engel, Charles C·CNS spectrums·2006

This paper discusses two different ways to approach studying and treating illnesses like ME/CFS that don't have a clear, well-understood cause. One approach focuses on finding the root cause in controlled settings; the other focuses on whether treatments actually work in real-world patient care. The authors argue that for conditions like ME/CFS, the practical approach—focusing on what helps patients in everyday life—may be more useful than searching for a single underlying cause.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Cognitive dysfunction in fibromyalgia and chronic fatigue syndrome: new trends and future directions.

Glass, Jennifer M·Current rheumatology reports·2006

Many people with fibromyalgia and chronic fatigue syndrome report problems with memory and thinking clearly. When researchers tested these patients' cognitive abilities, they found real difficulties with memory and how quickly patients process information. Brain imaging studies showed that patients' brains work differently during thinking tasks, requiring more activation than expected.

Cognitive Impairment

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Evidence browser

[On the important role of Siguan points in treatment of chronic fatigue syndrome].

Protective efficacy, immunotherapeutic potential, and safety of hepatitis B vaccines.

Conceptual issues in undifferentiated somatoform disorder and chronic fatigue syndrome.

[Chronic fatigue syndrome--exercise and physical activity].

Highlights from 5th International Conference on HHV-6 and -7.

[The chronic fatigue syndrome and its diagnosis in internal medicine].

Toward a trajectory of identity reconstruction in chronic fatigue syndrome/myalgic encephalomyelitis: a longitudinal qualitative study.

Brain cytokines and the 5-HT system during poly I:C-induced fatigue.

[Chronic fatigue syndrome in cardiology neurohumoral changes].

The challenge of integrating disparate high-content data: epidemiological, clinical and laboratory data collected during an in-hospital study of chronic fatigue syndrome.

Is human herpesvirus-6 a trigger for chronic fatigue syndrome?

Identifying illness parameters in fatiguing syndromes using classical projection methods.

[Neuropsychiatric symptoms related to interferon alpha].

Chronic fatigue syndrome is accompanied by an IgM-related immune response directed against neopitopes formed by oxidative or nitrosative damage to lipids and proteins.

Chronic Fatigue Syndrome: An Evaluation of a Community Based Management Programme for Adolescents and their Families.

Chronic fatigue syndrome.

Proton and 31-phosphorus neurospectroscopy in the study of membrane phospholipids and fatty acid intervention in schizophrenia, depression, chronic fatigue syndrome (myalgic encephalomyelitis) and dyslexia.

Brief and distinct empirical sleepiness and fatigue scales.

Explanatory and pragmatic perspectives regarding idiopathic physical symptoms and related syndromes.

Cognitive dysfunction in fibromyalgia and chronic fatigue syndrome: new trends and future directions.

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Metabolism & Mitochondria

Biomarkers

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