ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

1601–1620 of 2,422 studies

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Exploration of statistical dependence between illness parameters using the entropy correlation coefficient.

Craddock, R Cameron, Taylor, Renee, Broderick, Gordon et al.·Pharmacogenomics·2006

Researchers tested a new statistical method called the entropy correlation coefficient to identify which ME/CFS symptoms and test results are related to each other. They studied 130 women and found that fatigue-related measures were strongly connected to each other, as were general quality-of-life measures and depression scores. Importantly, they discovered some relationships between cognitive test results and ME/CFS that hadn't been found with traditional statistical methods.

Cognitive Impairment

E3 PreliminaryCohortPEM not requiredCase-Control

Four problems with the clinical control of interstitial pneumonia, or chronic fatigue syndrome, using the megadose vitamin C infusion system with dehydroepiandrosterone-cortisol annex.

Kodama, Mitsuo, Kodama, Toshiko·In vivo (Athens, Greece)·2006

This study describes a clinic's experience treating patients with interstitial pneumonia (a lung condition) using high-dose vitamin C infusions combined with hormones and antibiotics since 1996. The authors discuss four main challenges they encountered: deciding whether to continue treatment when patients seemed stable, dealing with bacteria becoming resistant to antibiotics, observing bone marrow damage in one patient, and noting one patient developed breast cancer during treatment.

Immune System

E3 PreliminaryCohortPEM not requiredCross-Sectional

Reduced responsiveness is an essential feature of chronic fatigue syndrome: a fMRI study.

Tanaka, Masaaki, Sadato, Norihiro, Okada, Tomohisa et al.·BMC neurology·2006

Researchers used brain imaging to compare how the brains of ME/CFS patients and healthy people responded to sounds while doing a tiring visual task. They found that healthy people's brains stayed responsive to sounds during the task, but ME/CFS patients' brains showed reduced responses to sounds—and this reduction matched how fatigued the patients felt. This suggests that ME/CFS may involve the brain becoming less able to process information that isn't directly related to the main task at hand.

Cognitive Impairment

E3 PreliminaryCohortPEM not requiredObservational

Submaximal aerobic exercise with mechanical vibrations improves the functional status of patients with chronic fatigue syndrome.

Saggini, R, Vecchiet, J, Iezzi, S et al.·Europa medicophysica·2006

This small study tested whether a special exercise machine that combines gentle exercise with vibrations could help ME/CFS patients feel better. Ten patients did submaximal aerobic exercise using a Galileo 2000 device over six months. After the treatment, patients reported improvements in pain sensitivity, fatigue, and muscle strength compared to before they started.

E3 PreliminaryCohortPEM not requiredCase-Control

Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes predict chronic fatigue syndrome.

Goertzel, Benjamin N, Pennachin, Cassio, de Souza Coelho, Lucio et al.·Pharmacogenomics·2006

Researchers looked at genetic variations (called SNPs) in genes related to stress hormones and brain chemistry to see if they could predict who has ME/CFS. Using patterns from 28 specific genetic variants, they correctly identified ME/CFS in about 76% of patients tested. This suggests that genetics play a role in ME/CFS, though genes are not the whole story.

Endocrine Disruption

E3 PreliminaryReviewPEM unclearReview-Narrative

Postulated vasoactive neuropeptide autoimmunity in fatigue-related conditions: a brief review and hypothesis.

Staines, Donald R·Clinical & developmental immunology·2006

This paper proposes that ME/CFS and similar conditions may develop when the immune system mistakenly attacks certain chemical messengers in the body called vasoactive neuropeptides (VNs). These VNs normally help control heart rate, breathing, temperature, memory, and mood. The authors suggest that after infections or other triggers, people's bodies may lose the ability to recognize these messengers as 'self,' leading to immune attacks that could cause the widespread symptoms seen in ME/CFS.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

[Multiple chemical sensitivity in sick-building syndrome].

Arnold Llamosas, Pablo A, Arrizabalaga Clemente, Pilar, Bonet Agusti, Montserrat et al.·Medicina clinica·2006

This study describes a dialysis worker who developed severe chronic fatigue and chemical sensitivities after prolonged exposure to poor indoor air quality in a poorly ventilated building. The person experienced eye irritation, breathing problems, and other symptoms that improved when the environmental conditions were examined and their connection to the illness was confirmed. The case highlights that healthcare facilities can expose workers to unhealthy air and chemical environments that may trigger ME/CFS-like illnesses.

Pain and Sensitization

E3 PreliminaryMechanismPEM not requiredMechanistic

Gene expression profile exploration of a large dataset on chronic fatigue syndrome.

Fang, Hong, Xie, Qian, Boneva, Roumiana et al.·Pharmacogenomics·2006

Researchers studied the genes that are turned on or off differently in people with ME/CFS compared to healthy controls. They looked at blood samples from 167 people and used computer analysis to identify 24 key genes and 11 biological pathways that appear to be involved in ME/CFS. These genes are involved in immune function, cell communication, and nerve activity—areas that scientists already suspect play a role in the illness.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Interpreter of maladies: redescription mining applied to biomedical data analysis.

Waltman, Peter, Pearlman, Alex, Mishra, Bud·Pharmacogenomics·2006

This paper describes a new computational method for analyzing complex medical data to better understand disease causes. The authors explain how combining genetic, protein, and clinical information from patients and healthy people can reveal hidden patterns that explain why diseases like ME/CFS occur and progress. They demonstrate this approach using a large CDC dataset from patients with ME/CFS.

Biomarkers

E3 PreliminaryReviewPEM not requiredReview-Narrative

Protective efficacy, immunotherapeutic potential, and safety of hepatitis B vaccines.

Zuckerman, Jane N·Journal of medical virology·2006

This review examines hepatitis B vaccines, which are widely used and have an excellent safety record across over 150 countries. The authors specifically addressed concerns about whether these vaccines cause chronic fatigue syndrome, and found no evidence of such a connection. The study looked at how well these vaccines work, why some people don't respond to them, and potential new ways to use them to treat hepatitis B infection.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Conceptual issues in undifferentiated somatoform disorder and chronic fatigue syndrome.

van Staden, Werdie C W·Current opinion in psychiatry·2006

This paper examines why it can be difficult to distinguish between two conditions that both cause severe tiredness: undifferentiated somatoform disorder (a condition where physical symptoms occur without clear medical causes) and ME/CFS. The author argues that a key difference may be how patients experience their fatigue—some describe it as purely physical rather than mental—and that this distinction has not been properly studied or recognized in ME/CFS research.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Proton and 31-phosphorus neurospectroscopy in the study of membrane phospholipids and fatty acid intervention in schizophrenia, depression, chronic fatigue syndrome (myalgic encephalomyelitis) and dyslexia.

Puri, Basant K·International review of psychiatry (Abingdon, England)·2006

This study describes advanced brain imaging techniques that can measure specific chemicals in the brain without surgery. These techniques help researchers understand how the brain uses fats and other building blocks to maintain healthy cell membranes. The authors explain how these imaging methods could be applied to study brain chemistry in ME/CFS and other conditions.

Energy Metabolism

E3 PreliminaryReviewPEM not requiredReview-Narrative

Illnesses you have to fight to get: facts as forces in uncertain, emergent illnesses.

Dumit, Joseph·Social science & medicine (1982)·2006

This study examines why ME/CFS and multiple chemical sensitivity remain controversial and hard to get diagnosed. Researchers found that patients often struggle because doctors and institutions lack clear biological evidence for these illnesses, and they use scientific uncertainty as a reason to deny patients care and legitimacy. Patients have responded by documenting these exclusions and developing their own strategies to fight back.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Is human herpesvirus-6 a trigger for chronic fatigue syndrome?

Komaroff, Anthony L·Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2006

This study reviews evidence about whether a virus called human herpesvirus-6 (HHV-6) might cause ME/CFS. Researchers found that active HHV-6 infection appears more frequently in ME/CFS patients than in healthy people, and the virus may be connected to some of the nervous system and immune system problems seen in ME/CFS. However, not all ME/CFS patients test positive for active HHV-6, suggesting it may only trigger the illness in some people.

Immune System

E3 PreliminaryBehavioralPEM unclearCross-Sectional

Illness Beliefs in Chronic Fatigue Syndrome: A Study Involving Affected Adolescents and their Parents.

Richards, Jo, Chaplin, Robert, Starkey, Caroline et al.·Child and adolescent mental health·2006

This study asked 21 young people with ME/CFS and their parents about what they thought caused the illness and how they managed it. Most people believed the illness started from an infection, while fewer thought it was psychological. Many found that resting and reducing activity helped manage symptoms. The study highlights that doctors should listen carefully to what patients and families believe about ME/CFS before deciding on treatment.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

High-resolution magnetic resonance imaging sinc-interpolation-based subvoxel registration and semi-automated quantitative lateral ventricular morphology employing threshold computation and binary image creation in the study of fatty acid interventions in schizophrenia, depression, chronic fatigue syndrome and Huntington's disease.

Puri, Basant K·International review of psychiatry (Abingdon, England)·2006

Researchers developed advanced brain imaging techniques to detect small structural changes in the brain over time by comparing multiple MRI scans with extremely high precision. They used these techniques to study whether a type of fish oil supplement (EPA) might affect brain structure in people with various conditions, including ME/CFS. This study focuses on the imaging methods themselves rather than reporting final results about whether the treatment worked.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Chronic fatigue syndrome is accompanied by an IgM-related immune response directed against neopitopes formed by oxidative or nitrosative damage to lipids and proteins.

Maes, Michael, Mihaylova, Ivana, Leunis, Jean-Claude·Neuro endocrinology letters·2006

This study found that people with ME/CFS have higher levels of immune antibodies (IgM) attacking damaged fats and proteins in their bodies. These antibodies target substances created when cells are damaged by oxidative stress—a harmful process where the body's natural defenses become imbalanced. The more severe someone's ME/CFS symptoms were, the higher their antibody levels tended to be.

BiomarkersImmune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome.

Devanur, L D, Kerr, J R·Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2006

ME/CFS affects about 1 in 100 to 1 in 250 people worldwide and is diagnosed based on clinical symptoms after ruling out other diseases. Research shows that ME/CFS likely involves multiple factors: immune system problems, stress, infections (such as Epstein-Barr virus), and exposure to certain chemicals or toxins. Currently there is no proven cure, but treating underlying infections may help some patients.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The challenge of integrating disparate high-content data: epidemiological, clinical and laboratory data collected during an in-hospital study of chronic fatigue syndrome.

Vernon, Suzanne D, Reeves, William C·Pharmacogenomics·2006

Researchers invited people with ME/CFS, people with other unexplained fatigue illnesses, and healthy controls to stay in a hospital for 2 days. During the visit, they measured brain chemicals, nervous system function, immune markers, and gene activity. A team of 20 scientists from different fields worked together to find new ways to understand all this information and look for biological markers that might explain ME/CFS.

Sleep

E3 PreliminaryMechanismPEM not requiredObservational

Exploration of the gene expression correlates of chronic unexplained fatigue using factor analysis.

Fostel, Jennifer, Boneva, Roumiana, Lloyd, Andrew·Pharmacogenomics·2006

Researchers used blood tests and symptom questionnaires to look for biological markers that could help identify ME/CFS. They found that ME/CFS involves multiple symptom patterns (fatigue and mood changes being most prominent) and identified 57 genes whose activity differed between people with severe symptoms and those with mild symptoms. However, no single gene or blood test on its own clearly identifies the disease.

Biomarkers

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Exploration of statistical dependence between illness parameters using the entropy correlation coefficient.

Four problems with the clinical control of interstitial pneumonia, or chronic fatigue syndrome, using the megadose vitamin C infusion system with dehydroepiandrosterone-cortisol annex.

Reduced responsiveness is an essential feature of chronic fatigue syndrome: a fMRI study.

Submaximal aerobic exercise with mechanical vibrations improves the functional status of patients with chronic fatigue syndrome.

Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes predict chronic fatigue syndrome.

Postulated vasoactive neuropeptide autoimmunity in fatigue-related conditions: a brief review and hypothesis.

[Multiple chemical sensitivity in sick-building syndrome].

Gene expression profile exploration of a large dataset on chronic fatigue syndrome.

Interpreter of maladies: redescription mining applied to biomedical data analysis.

Protective efficacy, immunotherapeutic potential, and safety of hepatitis B vaccines.

Conceptual issues in undifferentiated somatoform disorder and chronic fatigue syndrome.

Proton and 31-phosphorus neurospectroscopy in the study of membrane phospholipids and fatty acid intervention in schizophrenia, depression, chronic fatigue syndrome (myalgic encephalomyelitis) and dyslexia.

Illnesses you have to fight to get: facts as forces in uncertain, emergent illnesses.

Is human herpesvirus-6 a trigger for chronic fatigue syndrome?

Illness Beliefs in Chronic Fatigue Syndrome: A Study Involving Affected Adolescents and their Parents.

Chronic fatigue syndrome is accompanied by an IgM-related immune response directed against neopitopes formed by oxidative or nitrosative damage to lipids and proteins.

Chronic fatigue syndrome.

The challenge of integrating disparate high-content data: epidemiological, clinical and laboratory data collected during an in-hospital study of chronic fatigue syndrome.

Exploration of the gene expression correlates of chronic unexplained fatigue using factor analysis.

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