ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1601–1620 of 2,423 studies

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

High-resolution magnetic resonance imaging sinc-interpolation-based subvoxel registration and semi-automated quantitative lateral ventricular morphology employing threshold computation and binary image creation in the study of fatty acid interventions in schizophrenia, depression, chronic fatigue syndrome and Huntington's disease.

Puri, Basant K·International review of psychiatry (Abingdon, England)·2006

Researchers developed advanced brain imaging techniques to detect small structural changes in the brain over time by comparing multiple MRI scans with extremely high precision. They used these techniques to study whether a type of fish oil supplement (EPA) might affect brain structure in people with various conditions, including ME/CFS. This study focuses on the imaging methods themselves rather than reporting final results about whether the treatment worked.

E3 PreliminaryBehavioralPEM unclearCross-Sectional

Illness Beliefs in Chronic Fatigue Syndrome: A Study Involving Affected Adolescents and their Parents.

Richards, Jo, Chaplin, Robert, Starkey, Caroline et al.·Child and adolescent mental health·2006

This study asked 21 young people with ME/CFS and their parents about what they thought caused the illness and how they managed it. Most people believed the illness started from an infection, while fewer thought it was psychological. Many found that resting and reducing activity helped manage symptoms. The study highlights that doctors should listen carefully to what patients and families believe about ME/CFS before deciding on treatment.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome.

Devanur, L D, Kerr, J R·Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2006

ME/CFS affects about 1 in 100 to 1 in 250 people worldwide and is diagnosed based on clinical symptoms after ruling out other diseases. Research shows that ME/CFS likely involves multiple factors: immune system problems, stress, infections (such as Epstein-Barr virus), and exposure to certain chemicals or toxins. Currently there is no proven cure, but treating underlying infections may help some patients.

Immune System

E3 PreliminaryCohortPEM unclearCase-Control

Efficacy of neurotropin in chronic fatigue syndrome: a case report.

Toda, Katsuhiro, Kimura, Hiroaki·Hiroshima journal of medical sciences·2006

This case report describes one 28-year-old man with ME/CFS who was treated with a medication called Neurotropin (four tablets daily). His fatigue and widespread pain began improving within a week, and his sleep, focus, and memory improved within two weeks. He stopped taking the medication after 11 weeks and remained symptom-free for at least 5 months afterward.

Pain and SensitizationSleepCognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

Protective efficacy, immunotherapeutic potential, and safety of hepatitis B vaccines.

Zuckerman, Jane N·Journal of medical virology·2006

This review examines hepatitis B vaccines, which are widely used and have an excellent safety record across over 150 countries. The authors specifically addressed concerns about whether these vaccines cause chronic fatigue syndrome, and found no evidence of such a connection. The study looked at how well these vaccines work, why some people don't respond to them, and potential new ways to use them to treat hepatitis B infection.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Contribution of gender to pathophysiology and clinical presentation of IBS: should management be different in women?

Ouyang, Ann, Wrzos, Helena F·The American journal of gastroenterology·2006

This review article examines why irritable bowel syndrome (IBS)—a condition causing digestive discomfort—affects more women than men. The authors discuss how biological sex differences, hormones, and gender roles may influence who develops IBS and how severe their symptoms are. They suggest that while men and women are treated similarly for IBS, paying attention to stress and gender-specific factors might improve care.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[The problem of fatigue in neurological disorders].

Kumor, Klaudiusz, Pierzchała, Krystyna·Wiadomosci lekarskie (Warsaw, Poland : 1960)·2006

Fatigue is an extremely common and often severely disabling symptom in many neurological disorders, affecting 40–90% of patients with conditions like multiple sclerosis, Parkinson's disease, and stroke. This review explains that fatigue is a real medical symptom that should be carefully distinguished from depression, weakness, and sleepiness, though these conditions often occur together. Currently, doctors assess fatigue mainly through patient questionnaires, and there is no clear biological test or proven cure—treatments focus on addressing the underlying disease and using behavioral and psychological approaches.

Diagnostics

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Exploration of statistical dependence between illness parameters using the entropy correlation coefficient.

Craddock, R Cameron, Taylor, Renee, Broderick, Gordon et al.·Pharmacogenomics·2006

Researchers tested a new statistical method called the entropy correlation coefficient to identify which ME/CFS symptoms and test results are related to each other. They studied 130 women and found that fatigue-related measures were strongly connected to each other, as were general quality-of-life measures and depression scores. Importantly, they discovered some relationships between cognitive test results and ME/CFS that hadn't been found with traditional statistical methods.

Cognitive Impairment

E3 PreliminaryMechanismPEM not requiredMechanistic

Antidepressant-like activity of a Kampo (Japanese herbal) medicine, Koso-san (Xiang-Su-San), and its mode of action via the hypothalamic-pituitary-adrenal axis.

Ito, N, Nagai, T, Yabe, T et al.·Phytomedicine : international journal of phytotherapy and phytopharmacology·2006

This study tested whether Koso-san, a traditional Japanese herbal medicine, could help reduce depression-like symptoms in mice exposed to stress. Mice given Koso-san showed improved behavior in stress tests, and the herb appeared to normalize stress hormone systems in their brains that were overactive due to the stress exposure.

Endocrine Disruption

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The challenge of integrating disparate high-content data: epidemiological, clinical and laboratory data collected during an in-hospital study of chronic fatigue syndrome.

Vernon, Suzanne D, Reeves, William C·Pharmacogenomics·2006

Researchers invited people with ME/CFS, people with other unexplained fatigue illnesses, and healthy controls to stay in a hospital for 2 days. During the visit, they measured brain chemicals, nervous system function, immune markers, and gene activity. A team of 20 scientists from different fields worked together to find new ways to understand all this information and look for biological markers that might explain ME/CFS.

Sleep

E3 PreliminaryReviewPEM unclearReview-Narrative

[Possible mechanisms of chronic fatigue syndrome in multiple sclerosis].

Kasatkin, D S, Spirin, N N·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2006

This review describes how fatigue in multiple sclerosis (MS) can happen in different ways: tiredness even at rest, exhaustion during activity, and fatigue linked to MS flare-ups. The authors explain that fatigue likely involves both brain-based and body-based mechanisms, and often occurs alongside depression and sleep problems, suggesting these conditions may share common biological causes related to brain chemicals like serotonin.

NeuroinflammationPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia, infection and vaccination: two more parts in the etiological puzzle.

Ablin, Jacob N, Shoenfeld, Yehuda, Buskila, Dan·Journal of autoimmunity·2006

This review examines whether infections and vaccinations might trigger fibromyalgia and related conditions like chronic fatigue syndrome. Researchers found that certain infections (like Lyme disease and hepatitis C) have been linked to fibromyalgia, and some people report symptoms starting after vaccinations, but antibiotics and antivirals don't appear to help treat fibromyalgia effectively. The authors suggest that vaccinations might act as one trigger among several factors that together cause these conditions.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome].

Maoz, Daniel, Shoenfeld, Yehuda·Harefuah·2006

ME/CFS is a serious illness that causes extreme tiredness and other symptoms that interfere with daily life. Doctors often fail to diagnose it correctly, and we still don't fully understand what causes it. This review suggests that ME/CFS likely results from multiple different factors working together, and that two treatments—cognitive behavioral therapy and graded exercise therapy—might help some patients.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Postulated vasoactive neuropeptide autoimmunity in fatigue-related conditions: a brief review and hypothesis.

Staines, Donald R·Clinical & developmental immunology·2006

This paper proposes that ME/CFS and similar conditions may develop when the immune system mistakenly attacks certain chemical messengers in the body called vasoactive neuropeptides (VNs). These VNs normally help control heart rate, breathing, temperature, memory, and mood. The authors suggest that after infections or other triggers, people's bodies may lose the ability to recognize these messengers as 'self,' leading to immune attacks that could cause the widespread symptoms seen in ME/CFS.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Proton and 31-phosphorus neurospectroscopy in the study of membrane phospholipids and fatty acid intervention in schizophrenia, depression, chronic fatigue syndrome (myalgic encephalomyelitis) and dyslexia.

Puri, Basant K·International review of psychiatry (Abingdon, England)·2006

This study describes advanced brain imaging techniques that can measure specific chemicals in the brain without surgery. These techniques help researchers understand how the brain uses fats and other building blocks to maintain healthy cell membranes. The authors explain how these imaging methods could be applied to study brain chemistry in ME/CFS and other conditions.

Energy Metabolism

E3 PreliminaryBehavioralPEM not requiredObservational

Chronic Fatigue Syndrome: An Evaluation of a Community Based Management Programme for Adolescents and their Families.

Ashby, Bernadette, Wright, Barry, Jordan, Jo·Child and adolescent mental health·2006

This study looked at how a community-based treatment program helped young people with ME/CFS and their families. Researchers interviewed teenagers and parents about their experience with an approach that combined physical rehabilitation with attention to both body and mind. The families reported improvements across the key areas addressed, and most valued this collaborative treatment method.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Illnesses you have to fight to get: facts as forces in uncertain, emergent illnesses.

Dumit, Joseph·Social science & medicine (1982)·2006

This study examines why ME/CFS and multiple chemical sensitivity remain controversial and hard to get diagnosed. Researchers found that patients often struggle because doctors and institutions lack clear biological evidence for these illnesses, and they use scientific uncertainty as a reason to deny patients care and legitimacy. Patients have responded by documenting these exclusions and developing their own strategies to fight back.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Beneficial effect of brewers' yeast extract on daily activity in a murine model of chronic fatigue syndrome.

Takahashi, Takashi, Yu, Fei, Zhu, Shi-Jie et al.·Evidence-based complementary and alternative medicine : eCAM·2006

Researchers gave mice a brewer's yeast extract to see if it could help restore activity levels in a mouse model of ME/CFS. Mice treated with the yeast extract showed significantly better activity levels compared to untreated mice, and the treated mice also had better survival rates. The study suggests that brewer's yeast extract may help by adjusting immune system responses that become imbalanced in ME/CFS.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Gene expression correlates of unexplained fatigue.

Whistler, Toni, Taylor, Renee, Craddock, R Cameron et al.·Pharmacogenomics·2006

Researchers examined blood samples from hundreds of people to find which genes are connected to fatigue in ME/CFS. They looked at over 20,000 genes and found that 839 of them showed a relationship with fatigue levels. Many of these genes are involved in energy production and metabolism in the body, though about half of the genes they found don't yet have clear functions identified.

Energy Metabolism

E3 PreliminaryCommentaryPEM not requiredEditorial

Challenges for molecular profiling of chronic fatigue syndrome.

Vernon, Suzanne D, Whistler, Toni, Aslakson, Eric et al.·Pharmacogenomics·2006

This paper discusses why it's been difficult for scientists to find reliable blood tests (biomarkers) to diagnose ME/CFS and develop treatments. The authors explain that ME/CFS is complex because it affects many body systems at once, and each researcher may focus on different areas based on their expertise. They suggest that blood tests show promise for understanding ME/CFS and that combining genetic information, protein data, and information about patients' environments and behaviors could help researchers better understand why different patients experience the illness differently.

Diagnostics

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Evidence browser

Illness Beliefs in Chronic Fatigue Syndrome: A Study Involving Affected Adolescents and their Parents.

Chronic fatigue syndrome.

Efficacy of neurotropin in chronic fatigue syndrome: a case report.

Protective efficacy, immunotherapeutic potential, and safety of hepatitis B vaccines.

Contribution of gender to pathophysiology and clinical presentation of IBS: should management be different in women?

[The problem of fatigue in neurological disorders].

Exploration of statistical dependence between illness parameters using the entropy correlation coefficient.

Antidepressant-like activity of a Kampo (Japanese herbal) medicine, Koso-san (Xiang-Su-San), and its mode of action via the hypothalamic-pituitary-adrenal axis.

The challenge of integrating disparate high-content data: epidemiological, clinical and laboratory data collected during an in-hospital study of chronic fatigue syndrome.

[Possible mechanisms of chronic fatigue syndrome in multiple sclerosis].

Fibromyalgia, infection and vaccination: two more parts in the etiological puzzle.

[Chronic fatigue syndrome].

Postulated vasoactive neuropeptide autoimmunity in fatigue-related conditions: a brief review and hypothesis.

Proton and 31-phosphorus neurospectroscopy in the study of membrane phospholipids and fatty acid intervention in schizophrenia, depression, chronic fatigue syndrome (myalgic encephalomyelitis) and dyslexia.

Chronic Fatigue Syndrome: An Evaluation of a Community Based Management Programme for Adolescents and their Families.

Illnesses you have to fight to get: facts as forces in uncertain, emergent illnesses.

Beneficial effect of brewers' yeast extract on daily activity in a murine model of chronic fatigue syndrome.

Gene expression correlates of unexplained fatigue.

Challenges for molecular profiling of chronic fatigue syndrome.

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