ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1601–1620 of 2,420 studies

E3 PreliminaryCommentaryPEM not requiredEditorial

Psychomotor speed: possibly a new marker for overtraining syndrome.

Nederhof, Esther, Lemmink, Koen A P M, Visscher, Chris et al.·Sports medicine (Auckland, N.Z.)·2006

This study proposes that measuring how quickly someone can respond to mental tasks (psychomotor speed) might help identify athletes who are overtraining before serious problems develop. The researchers noticed that overtraining syndrome shares some features with chronic fatigue syndrome and depression, both of which involve slowed mental processing, and suggest this slowness could be an early warning sign.

Cognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

Explanatory and pragmatic perspectives regarding idiopathic physical symptoms and related syndromes.

Engel, Charles C·CNS spectrums·2006

This paper discusses two different ways to approach studying and treating illnesses like ME/CFS that don't have a clear, well-understood cause. One approach focuses on finding the root cause in controlled settings; the other focuses on whether treatments actually work in real-world patient care. The authors argue that for conditions like ME/CFS, the practical approach—focusing on what helps patients in everyday life—may be more useful than searching for a single underlying cause.

Diagnostics

E3 PreliminaryPEM unclear

The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study.

Teitelbaum, Jacob E, Johnson, Clarence, St Cyr, John·Journal of alternative and complementary medicine (New York, N.Y.)·2006

Researchers gave 41 patients with ME/CFS or fibromyalgia a natural sugar called D-ribose to see if it could help their symptoms. Two-thirds of patients reported feeling noticeably better, with improvements in energy, sleep, mental clarity, pain, and overall well-being. The supplement was well-tolerated with no serious side effects reported.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

Highlights from 5th International Conference on HHV-6 and -7.

Komaroff, Anthony L, Jacobson, Steven, Ablashi, Dharam V et al.·Herpes : the journal of the IHMF·2006

Scientists at an international conference discussed new tests to detect two common viruses (HHV-6 and HHV-7) in the body and whether they might trigger nervous system diseases. These viruses can infect brain cells, and researchers think they may play a role in conditions like chronic fatigue syndrome, along with multiple sclerosis and other neurological problems. Better tests are being developed to tell if someone has an active infection or just carries the virus dormant.

E3 PreliminaryBehavioralPEM unclearLongitudinal

Toward a trajectory of identity reconstruction in chronic fatigue syndrome/myalgic encephalomyelitis: a longitudinal qualitative study.

Whitehead, Lisa·International journal of nursing studies·2006

This study followed 17 people with ME/CFS over time to understand how the illness changed how they saw themselves. The researchers found that people's sense of identity shifted depending on how sick they were and how others treated them. Over the long term, most people developed ways to cope that helped them build a more stable sense of who they were, even while managing their illness.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome in cardiology neurohumoral changes].

Iasiukiavichene, L, Vasiliauskas, D·Kardiologiia·2006

This review examines why people with heart disease often experience severe fatigue and how the body's stress response system may be involved. The authors explain that chronic fatigue is a condition affecting the immune system, hormones, and nervous system, and can be triggered by stress, surgery, infections, or other illnesses. They suggest that measuring a stress hormone called cortisol could help doctors identify and treat fatigue in heart patients.

Endocrine Disruption

E3 PreliminaryReviewPEM unclearReview-Narrative

Conceptual issues in undifferentiated somatoform disorder and chronic fatigue syndrome.

van Staden, Werdie C W·Current opinion in psychiatry·2006

This paper examines why it can be difficult to distinguish between two conditions that both cause severe tiredness: undifferentiated somatoform disorder (a condition where physical symptoms occur without clear medical causes) and ME/CFS. The author argues that a key difference may be how patients experience their fatigue—some describe it as purely physical rather than mental—and that this distinction has not been properly studied or recognized in ME/CFS research.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Proton and 31-phosphorus neurospectroscopy in the study of membrane phospholipids and fatty acid intervention in schizophrenia, depression, chronic fatigue syndrome (myalgic encephalomyelitis) and dyslexia.

Puri, Basant K·International review of psychiatry (Abingdon, England)·2006

This study describes advanced brain imaging techniques that can measure specific chemicals in the brain without surgery. These techniques help researchers understand how the brain uses fats and other building blocks to maintain healthy cell membranes. The authors explain how these imaging methods could be applied to study brain chemistry in ME/CFS and other conditions.

Energy Metabolism

E3 PreliminaryReviewPEM not requiredReview-Narrative

Is human herpesvirus-6 a trigger for chronic fatigue syndrome?

Komaroff, Anthony L·Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2006

This study reviews evidence about whether a virus called human herpesvirus-6 (HHV-6) might cause ME/CFS. Researchers found that active HHV-6 infection appears more frequently in ME/CFS patients than in healthy people, and the virus may be connected to some of the nervous system and immune system problems seen in ME/CFS. However, not all ME/CFS patients test positive for active HHV-6, suggesting it may only trigger the illness in some people.

Immune System

E3 PreliminaryBehavioralPEM unclearCross-Sectional

Illness Beliefs in Chronic Fatigue Syndrome: A Study Involving Affected Adolescents and their Parents.

Richards, Jo, Chaplin, Robert, Starkey, Caroline et al.·Child and adolescent mental health·2006

This study asked 21 young people with ME/CFS and their parents about what they thought caused the illness and how they managed it. Most people believed the illness started from an infection, while fewer thought it was psychological. Many found that resting and reducing activity helped manage symptoms. The study highlights that doctors should listen carefully to what patients and families believe about ME/CFS before deciding on treatment.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

High-resolution magnetic resonance imaging sinc-interpolation-based subvoxel registration and semi-automated quantitative lateral ventricular morphology employing threshold computation and binary image creation in the study of fatty acid interventions in schizophrenia, depression, chronic fatigue syndrome and Huntington's disease.

Puri, Basant K·International review of psychiatry (Abingdon, England)·2006

Researchers developed advanced brain imaging techniques to detect small structural changes in the brain over time by comparing multiple MRI scans with extremely high precision. They used these techniques to study whether a type of fish oil supplement (EPA) might affect brain structure in people with various conditions, including ME/CFS. This study focuses on the imaging methods themselves rather than reporting final results about whether the treatment worked.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome.

Devanur, L D, Kerr, J R·Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2006

ME/CFS affects about 1 in 100 to 1 in 250 people worldwide and is diagnosed based on clinical symptoms after ruling out other diseases. Research shows that ME/CFS likely involves multiple factors: immune system problems, stress, infections (such as Epstein-Barr virus), and exposure to certain chemicals or toxins. Currently there is no proven cure, but treating underlying infections may help some patients.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Cardiovascular systemic regulation by plantar surface stimulation.

Madhavan, Guruprasad, Stewart, Julian M, McLeod, Kenneth J·Biomedical instrumentation & technology·2006

This study tested whether gentle vibrations applied to the bottom of the foot could help stabilize blood pressure and heart rate when people sit down. Researchers found that vibrations at a specific frequency (around 44 Hz) significantly reduced the normal drop in blood pressure that occurs with sitting, and were especially helpful for people whose blood pressure drops excessively.

Autonomic Nervous System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Interpreter of maladies: redescription mining applied to biomedical data analysis.

Waltman, Peter, Pearlman, Alex, Mishra, Bud·Pharmacogenomics·2006

This paper describes a new computational method for analyzing complex medical data to better understand disease causes. The authors explain how combining genetic, protein, and clinical information from patients and healthy people can reveal hidden patterns that explain why diseases like ME/CFS occur and progress. They demonstrate this approach using a large CDC dataset from patients with ME/CFS.

Biomarkers

E3 PreliminaryBehavioralPEM not requiredObservational

Chronic Fatigue Syndrome: An Evaluation of a Community Based Management Programme for Adolescents and their Families.

Ashby, Bernadette, Wright, Barry, Jordan, Jo·Child and adolescent mental health·2006

This study looked at how a community-based treatment program helped young people with ME/CFS and their families. Researchers interviewed teenagers and parents about their experience with an approach that combined physical rehabilitation with attention to both body and mind. The families reported improvements across the key areas addressed, and most valued this collaborative treatment method.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Protective efficacy, immunotherapeutic potential, and safety of hepatitis B vaccines.

Zuckerman, Jane N·Journal of medical virology·2006

This review examines hepatitis B vaccines, which are widely used and have an excellent safety record across over 150 countries. The authors specifically addressed concerns about whether these vaccines cause chronic fatigue syndrome, and found no evidence of such a connection. The study looked at how well these vaccines work, why some people don't respond to them, and potential new ways to use them to treat hepatitis B infection.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Brief and distinct empirical sleepiness and fatigue scales.

Bailes, Sally, Libman, Eva, Baltzan, Marc et al.·Journal of psychosomatic research·2006

Doctors and patients often use the words 'sleepiness' and 'fatigue' interchangeably, but they actually describe different experiences. This study created two short, separate questionnaires—one to measure sleepiness (the urge to sleep) and one to measure fatigue (overall exhaustion)—by pulling items from existing popular fatigue and sleepiness scales. Testing these new scales on people with ME/CFS, narcolepsy, and healthy controls showed they measure distinct conditions that may respond to different treatments.

SleepDiagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome.

Nursing times·2006

This article provides an overview of chronic fatigue syndrome (ME/CFS) for nursing professionals. It covers the basic understanding of the condition, its impact on patients, and how healthcare providers can better support people living with ME/CFS.

E3 PreliminaryMechanismPEM not requiredMechanistic

Brain cytokines and the 5-HT system during poly I:C-induced fatigue.

Katafuchi, Toshihiko, Kondo, Tetsuya, Take, Sachiko et al.·Annals of the New York Academy of Sciences·2006

This study investigated how the brain's immune system might cause fatigue by looking at what happens when rats are exposed to a viral-like trigger. Researchers found that certain immune molecules in the brain (interferons) increased while a key fatigue-related brain chemical (serotonin) decreased. When they gave the rats a medication that boosted serotonin activity, the fatigue improved, suggesting that low serotonin in a specific brain region may play a role in fatigue.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The challenge of integrating disparate high-content data: epidemiological, clinical and laboratory data collected during an in-hospital study of chronic fatigue syndrome.

Vernon, Suzanne D, Reeves, William C·Pharmacogenomics·2006

Researchers invited people with ME/CFS, people with other unexplained fatigue illnesses, and healthy controls to stay in a hospital for 2 days. During the visit, they measured brain chemicals, nervous system function, immune markers, and gene activity. A team of 20 scientists from different fields worked together to find new ways to understand all this information and look for biological markers that might explain ME/CFS.

Sleep

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Evidence browser

Psychomotor speed: possibly a new marker for overtraining syndrome.

Explanatory and pragmatic perspectives regarding idiopathic physical symptoms and related syndromes.

The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study.

Highlights from 5th International Conference on HHV-6 and -7.

Toward a trajectory of identity reconstruction in chronic fatigue syndrome/myalgic encephalomyelitis: a longitudinal qualitative study.

[Chronic fatigue syndrome in cardiology neurohumoral changes].

Conceptual issues in undifferentiated somatoform disorder and chronic fatigue syndrome.

Proton and 31-phosphorus neurospectroscopy in the study of membrane phospholipids and fatty acid intervention in schizophrenia, depression, chronic fatigue syndrome (myalgic encephalomyelitis) and dyslexia.

Is human herpesvirus-6 a trigger for chronic fatigue syndrome?

Illness Beliefs in Chronic Fatigue Syndrome: A Study Involving Affected Adolescents and their Parents.

Chronic fatigue syndrome.

Cardiovascular systemic regulation by plantar surface stimulation.

Interpreter of maladies: redescription mining applied to biomedical data analysis.

Chronic Fatigue Syndrome: An Evaluation of a Community Based Management Programme for Adolescents and their Families.

Protective efficacy, immunotherapeutic potential, and safety of hepatitis B vaccines.

Brief and distinct empirical sleepiness and fatigue scales.

Chronic fatigue syndrome.

Brain cytokines and the 5-HT system during poly I:C-induced fatigue.

The challenge of integrating disparate high-content data: epidemiological, clinical and laboratory data collected during an in-hospital study of chronic fatigue syndrome.

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Metabolism & Mitochondria

Biomarkers

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