ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1901–1920 of 2,423 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

DHEA. Monograph.

Alternative medicine review : a journal of clinical therapeutic·2001

This article reviews DHEA, a hormone naturally produced by your body that decreases as you age. Research suggests that lower DHEA levels may be connected to several conditions, including ME/CFS, heart disease, diabetes, and autoimmune diseases like lupus and rheumatoid arthritis. DHEA acts as a 'buffer hormone' that can be converted into other important hormones like estrogen and testosterone.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Physical activity for the chronically ill and disabled.

Durstine, J L, Painter, P, Franklin, B A et al.·Sports medicine (Auckland, N.Z.)·2000

This review article examines how exercise should be prescribed differently for people with chronic illnesses and disabilities compared to healthy people. The authors note that while exercise guidelines exist for conditions like heart disease, many chronic conditions—including ME/CFS—have received little scientific attention regarding safe and effective exercise recommendations. The key idea is that exercise plans need to be customized based on each person's individual health status rather than using one-size-fits-all approaches.

E3 PreliminaryPEM not required

Chronic fatigue syndrome in childhood.

Tomoda, A, Miike, T, Yamada, E et al.·Brain & development·2000

This study looked at three children (ages 11-13) with ME/CFS and used special brain imaging scans to measure blood flow and chemical activity in their brains. The scans showed differences in brain blood flow and metabolism compared to healthy children, suggesting that ME/CFS may involve changes in how the brain is functioning, not just a psychological problem.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Aspects of occupational disability in psychosomatic disorders].

Huber, M·Versicherungsmedizin·2000

This 2000 review describes how psychosomatic illnesses—conditions where physical and emotional health are closely connected—were a major reason people went on disability leave in the 1990s. The article discusses several conditions including chronic fatigue syndrome, fibromyalgia, and chronic pain disorders, and suggests that the best approach to help these patients is through teamwork between physical medicine doctors and mental health professionals early in the illness.

E3 PreliminaryReviewPEM not requiredReview-Narrative

The challenge of evaluating fatigue.

Rodriguez, T·Journal of the American Academy of Nurse Practitioners·2000

This article helps doctors and nurse practitioners understand how to properly evaluate fatigue in patients. It explains that fatigue can have many different causes and can be either short-term or long-term, and it's important to distinguish chronic fatigue from ME/CFS. The article suggests using specific tools and checklists to help identify what might be causing someone's fatigue so it can be properly treated.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Pain complaints in patients with fibromyalgia versus chronic fatigue syndrome.

Bradley, L A, McKendree-Smith, N L, Alarcón, G S·Current review of pain·2000

Both fibromyalgia (FM) and ME/CFS cause muscle and joint pain, but the underlying reasons differ between these conditions. People with FM alone have unusually sensitive pain responses to light touch or mild pressure (called allodynia), while people with ME/CFS do not typically show this. This study examined what brain and hormone system differences might explain why these two conditions cause pain in different ways.

Pain and Sensitization

E3 PreliminaryCommentaryPEM not requiredEditorial

Altered glucocorticoid regulation of the immune response in the chronic fatigue syndrome.

Visser, J T, De Kloet, E R, Nagelkerken, L·Annals of the New York Academy of Sciences·2000

This study explores how stress hormones called glucocorticoids affect the immune system in ME/CFS patients. The researchers found evidence suggesting that in ME/CFS, these stress hormones may be shifting the immune system's balance in an unhelpful way—boosting certain types of immune responses while weakening others. This could help explain why ME/CFS patients experience ongoing immune system problems.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Fibromyalgia in the year 2000].

Maquet, D, Croisier, J L, Crielaard, J M·Revue medicale de Liege·2000

This review article examines fibromyalgia (FM), a condition causing widespread muscle pain that affects about 2% of people. While doctors can diagnose fibromyalgia using a specific test (checking for tenderness at 18 specific body points), scientists still don't fully understand what causes it. This article summarizes what researchers knew in 2000 about how fibromyalgia develops and how doctors treat it.

Pain and Sensitization

E3 PreliminaryMechanismPEM unclearMechanistic

Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome.

Fulle, S, Mecocci, P, Fanó, G et al.·Free radical biology & medicine·2000

Researchers examined muscle tissue from ME/CFS patients and found signs of oxidative damage—a type of cellular wear and tear similar to rust forming on metal. The patients' muscles showed damage to DNA and fats in cells, and their bodies had ramped up production of protective chemicals called antioxidants to fight back against this damage. This suggests ME/CFS may cause real, measurable changes in how muscle cells function at a chemical level.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

Free radicals in chronic fatigue syndrome: cause or effect?

Richards, R S, Roberts, T K, Dunstan, R H et al.·Redox report : communications in free radical research·2000

This study looked at whether harmful molecules called free radicals might be involved in ME/CFS, similar to how they contribute to rheumatoid arthritis. The researchers found that ME/CFS patients showed certain body changes that resembled those seen in rheumatoid arthritis, suggesting free radicals could play a role in ME/CFS.

E3 PreliminaryCohortPEM not requiredObservational

Treatment of chronic fatigue syndrome with 5-HT3 receptor antagonists--preliminary results.

Späth, M, Welzel, D, Färber, L·Scandinavian journal of rheumatology. Supplement·2000

Researchers tested whether two medications that block serotonin receptors (tropisetron and ondansetron) might help ME/CFS patients feel less fatigued. About one third of the patients who took these medications reported meaningful improvement in fatigue and energy levels over 15 days, with no serious side effects reported.

Interventions

E3 PreliminaryReviewPEM not requiredReview-Narrative

Sleep and circadian rhythm disorders in fibromyalgia.

Korszun, A·Current rheumatology reports·2000

Fibromyalgia is a condition causing widespread muscle pain along with sleep problems and extreme tiredness. This review examines how broken sleep patterns and disrupted body clocks (which control things like stress hormones) play a role in fibromyalgia. The authors suggest that treating sleep disorders, depression, and improving sleep habits—along with careful use of medications—may help relieve symptoms.

Sleep

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Motor cortex excitability in chronic fatigue syndrome.

Starr, A, Scalise, A, Gordon, R et al.·Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2000

This study used a technique called transcranial magnetic stimulation (TMS) to measure how the motor cortex—the part of the brain that controls movement—behaves in people with ME/CFS. Patients and healthy controls performed finger movements while researchers measured brain responses before, during, and after the exercise. People with ME/CFS showed abnormal brain responses compared to healthy people, suggesting their brains may not adapt normally to physical activity.

E3 PreliminaryCohortPEM unclearCase-Control

An effective "transluminal balloon angioplasty" therapy for pediatric chronic fatigue syndrome with nutcracker phenomenon.

Takahashi, Y, Sano, A, Matsuo, M·Clinical nephrology·2000

This case report describes a small number of children with chronic fatigue syndrome who also had a rare blood vessel condition called 'nutcracker phenomenon,' where a vein becomes compressed. The researchers tried a procedure called balloon angioplasty (widening the compressed vessel) to see if it could help reduce fatigue symptoms. The study suggests this treatment may have helped some patients, but it involved only a few cases.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Follicular phase hypothalamic-pituitary-gonadal axis function in women with fibromyalgia and chronic fatigue syndrome.

Korszun, A, Young, E A, Engleberg, N C et al.·The Journal of rheumatology·2000

Researchers tested whether women with fibromyalgia (FM) and chronic fatigue syndrome (CFS) have imbalances in hormones related to reproduction and the menstrual cycle. They collected blood samples every 10 minutes over 12 hours from women with FM, women with CFS, and healthy controls during the first part of the menstrual cycle. They found no significant differences in hormone levels or patterns between the patient groups and healthy women.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome--the disease and approaches to treatment].

Apel-Paz, M, Lior, B, Shemesh-Kigli, R·Harefuah·2000

This review article examines ME/CFS, describing what the disease is and discussing different treatment approaches. The authors provide an overview of the condition and explore various ways doctors have tried to help patients manage their symptoms. This type of review helps bring together existing knowledge about the illness and its management.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Controversies in neurological infectious diseases.

Greenlee, J E, Rose, J W·Seminars in neurology·2000

This is a review article that discusses six controversial topics in infections affecting the nervous system. One of these topics is whether viruses might play a role in chronic fatigue syndrome (ME/CFS). The authors examine what scientists know and disagree about regarding these infections and their treatments.

E3 PreliminaryCohortPEM not requiredCase-Control

[Genioglossal advancement in the surgical treatment of obstructive sleep apnea syndrome in adults].

Foltán, R, Sonka, K·Sbornik lekarsky·2000

This case report describes a 68-year-old woman with severe sleep apnea (a condition where breathing repeatedly stops during sleep) who also had symptoms of chronic fatigue, daytime sleepiness, and morning headaches. Because she couldn't tolerate the standard breathing mask treatment due to anxiety, she had surgery to widen her airway. After surgery, her sleep apnea improved significantly and her fatigue and other symptoms improved.

Sleep

E3 PreliminaryCohortPEM unclearCross-Sectional

Search for Borna disease virus in Danish fibromyalgia patients.

Wittrup, I H, Christensen, L S, Jensen, B et al.·Scandinavian journal of rheumatology·2000

Researchers tested 18 patients with fibromyalgia (a condition causing widespread pain and fatigue) to see if they had a virus called Borna disease virus (BDV). This virus affects animals and had been suggested as a possible cause of chronic fatigue syndrome. The tests came back negative—BDV was not found in any of the patients' blood or spinal fluid samples.

E3 PreliminaryMechanismPEM not requiredObservational

The roles of orthostatic hypotension, orthostatic tachycardia, and subnormal erythrocyte volume in the pathogenesis of the chronic fatigue syndrome.

Streeten, D H, Thomas, D, Bell, D S·The American journal of the medical sciences·2000

This study found that many ME/CFS patients experience a sudden drop in blood pressure and abnormal heart rate acceleration when standing up, along with symptoms like dizziness. The researchers discovered that low red blood cell volume was present in most patients tested, and that wearing inflatable compression pants could quickly reverse these standing problems. This suggests that problems with blood pooling in the legs when upright may contribute to ME/CFS symptoms.

Autonomic Nervous System

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Evidence browser

DHEA. Monograph.

Physical activity for the chronically ill and disabled.

Chronic fatigue syndrome in childhood.

[Aspects of occupational disability in psychosomatic disorders].

The challenge of evaluating fatigue.

Pain complaints in patients with fibromyalgia versus chronic fatigue syndrome.

Altered glucocorticoid regulation of the immune response in the chronic fatigue syndrome.

[Fibromyalgia in the year 2000].

Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome.

Free radicals in chronic fatigue syndrome: cause or effect?

Treatment of chronic fatigue syndrome with 5-HT3 receptor antagonists--preliminary results.

Sleep and circadian rhythm disorders in fibromyalgia.

Motor cortex excitability in chronic fatigue syndrome.

An effective "transluminal balloon angioplasty" therapy for pediatric chronic fatigue syndrome with nutcracker phenomenon.

Follicular phase hypothalamic-pituitary-gonadal axis function in women with fibromyalgia and chronic fatigue syndrome.

[Chronic fatigue syndrome--the disease and approaches to treatment].

Controversies in neurological infectious diseases.

[Genioglossal advancement in the surgical treatment of obstructive sleep apnea syndrome in adults].

Search for Borna disease virus in Danish fibromyalgia patients.

The roles of orthostatic hypotension, orthostatic tachycardia, and subnormal erythrocyte volume in the pathogenesis of the chronic fatigue syndrome.

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