ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

821–840 of 1,198 studies

E3 PreliminaryPEM not requiredRegistry-Resource

The autoimmune/inflammatory syndrome induced by adjuvants (ASIA)/Shoenfeld's syndrome: descriptive analysis of 300 patients from the international ASIA syndrome registry.

Watad, Abdulla, Quaresma, Mariana, Bragazzi, Nicola Luigi et al.·Clinical rheumatology·2018

This study examined 300 patients who developed autoimmune diseases after exposure to adjuvants (immune-stimulating substances in vaccines and other products). The most common symptoms were joint pain, muscle pain, and chronic fatigue, and most patients developed another autoimmune condition within about 17 months of exposure. The researchers found that different adjuvants caused slightly different patterns of illness.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Stress, inflammation and natural treatments.

Theoharides, T C, Kavalioti, M·Journal of biological regulators and homeostatic agents·2018

This study explores how stress and inflammation work together to cause several conditions including ME/CFS, fibromyalgia, and others. The researchers found that immune cells called mast cells and brain cells called microglia may communicate in ways that trigger inflammation during stress. They suggest that a natural supplement combining luteolin and Ashwagandha might help reduce this inflammation and benefit patients with these conditions.

NeuroinflammationImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Dehydroepiandrosterone Research: Past, Current, and Future.

Klinge, Carolyn M, Clark, Barbara J, Prough, Russell A·Vitamins and hormones·2018

This is a historical review of dehydroepiandrosterone (DHEA), a hormone that naturally decreases with age. Scientists have studied whether DHEA might help with various health conditions including chronic fatigue syndrome, but the evidence in humans is limited. While some benefits have been found in postmenopausal women and certain autoimmune disorders, most human studies show only weak connections between DHEA levels and disease outcomes.

Energy MetabolismImmune System

E3 PreliminaryMechanismPEM requiredCross-Sectional

Investigation of mast cell toll-like receptor 3 in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Systemic Mastocytosis using the novel application of autoMACS magnetic separation and flow cytometry.

Balinas, Cassandra, Nguyen, Thao, Johnston, Samantha et al.·Asian Pacific journal of allergy and immunology·2018

This study looked at immune cells called mast cells in people with ME/CFS, comparing them to people with a known mast cell disorder and healthy volunteers. Mast cells help the body fight viruses and allergies. The researchers found differences in how these cells behave when exposed to viral-like substances, suggesting mast cells may play a role in ME/CFS symptoms.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Non-linear dose-response of aluminium hydroxide adjuvant particles: Selective low dose neurotoxicity.

Crépeaux, Guillemette, Eidi, Housam, David, Marie-Odile et al.·Toxicology·2017

This study gave mice different amounts of aluminum hydroxide (a substance used in vaccines) injected into muscle and then checked their brains 6 months later. Surprisingly, the mice that received the lowest dose showed cognitive and movement changes, increased immune cell activity in the brain, and accumulated more aluminum in their brains—while the mice given higher doses did not. This unusual pattern suggests that aluminum's harmful effects may not simply follow the traditional "more dose = more harm" rule.

NeuroinflammationImmune System

E3 PreliminaryMechanismPEM unclearMechanistic

Detection of Urine Metabolites in a Rat Model of Chronic Fatigue Syndrome before and after Exercise.

Shao, Changzhuan, Ren, Yiming, Wang, Zinan et al.·BioMed research international·2017

Researchers used rats exposed to stress and exercise to model ME/CFS and then measured chemicals in their urine before and after exercise. They found abnormalities in how the rats' bodies produce energy and process hormones, particularly in molecules called sphingosine and a hormone precursor called 21-hydroxypregnenolone. These findings suggest that ME/CFS may involve disrupted energy metabolism and problems with the body's stress-response system.

Energy MetabolismImmune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

[Effect of Acupuncture on the Expression of Transcription Factor T-bet/GATA-3 in Plasma of Rats with Chronic Fatigue Syndrome].

Wang, Xiang-Yi, Liu, Chang-Zheng, Lei, Bo·Zhen ci yan jiu = Acupuncture research·2017

Researchers tested whether acupuncture could help rats with chronic fatigue syndrome by measuring changes in immune system markers. Acupuncture was applied to three specific points for two weeks, and the treated rats showed improved tiredness and swimming performance compared to untreated rats. The study suggests acupuncture may work by rebalancing immune system signals that become disrupted in ME/CFS.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome.

Morris, Gerwyn, Berk, Michael, Klein, Hans et al.·Molecular neurobiology·2017

This study proposes that ME/CFS may be caused by a harmful process called 'hypernitrosylation,' where a molecule called nitric oxide damages proteins in cells, particularly those responsible for producing energy and fighting infections. When this damage becomes chronic, it can disable the body's natural repair systems and trigger the immune system to attack the body's own proteins. The researchers suggest this process could explain many ME/CFS symptoms, including fatigue, cognitive problems, and how bacterial toxins may trigger or worsen the disease.

NeuroinflammationImmune System

E3 PreliminaryMechanismPEM not requiredMechanistic

NLRP3 inflammasome activation mediates fatigue-like behaviors in mice via neuroinflammation.

Zhang, Ziteng, Ma, Xiujuan, Xia, Zhenna et al.·Neuroscience·2017

This study explored whether a specific immune system protein called NLRP3 might be involved in causing fatigue in mice. Researchers stressed mice with repeated swimming tests and found that stressed mice had higher levels of an inflammatory chemical (IL-1β) in their brains and showed fatigue-like behaviors. When they removed the NLRP3 protein in mice, the fatigue behaviors were reduced and inflammatory levels decreased, suggesting this protein may play a role in fatigue.

NeuroinflammationImmune System

E3 PreliminaryCohortPEM not requiredCase-Control

Two hundreds cases of ASIA syndrome following silicone implants: a comparative study of 30 years and a review of current literature.

Colaris, Maartje J L, de Boer, Mintsje, van der Hulst, Rene R et al.·Immunologic research·2017

This study compared 200 patients with silicone breast implants who developed autoimmune and inflammatory symptoms (a condition called ASIA) across two time periods—100 patients in 2014 and 100 historical patients from the 1980s–1990s. The researchers found that the symptoms remained similar over 30 years, including fatigue, joint pain, brain fog, and fever. About half of the patients who had their implants removed experienced symptom improvement.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM unclearMechanistic

Impaired calcium mobilization in natural killer cells from chronic fatigue syndrome/myalgic encephalomyelitis patients is associated with transient receptor potential melastatin 3 ion channels.

Nguyen, T, Johnston, S, Clarke, L et al.·Clinical and experimental immunology·2017

This study examined immune cells called natural killer cells in ME/CFS patients and healthy people to understand how calcium moves in and out of these cells. Researchers found that ME/CFS patients have lower levels of a specific channel (TRPM3) that helps control calcium movement in certain types of natural killer cells. The study suggests that problems with calcium signaling in these immune cells may contribute to how the immune system behaves differently in ME/CFS patients.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Efficacy of rintatolimod in the treatment of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME).

Mitchell, William M·Expert review of clinical pharmacology·2016

This review examines rintatolimod, a potential ME/CFS treatment that works by activating the immune system's antiviral defenses. The drug has shown promising results in clinical trials, with patients experiencing meaningful improvements in their symptoms and few serious side effects. This is important because ME/CFS currently has no approved medications, and rintatolimod represents one of the most advanced treatment options in development.

Immune System

E3 PreliminaryCommentaryPEM unclearEditorial

[Chronic fatigue syndrome: A new disorder?].

de Korwin, J-D, Chiche, L, Banovic, I et al.·La Revue de medecine interne·2016

This article reviews what we know about ME/CFS more than 30 years after it was first recognized as a distinct condition. The authors explain that ME/CFS likely results from multiple causes working together—such as infections that trigger the illness and ongoing problems with the immune system, inflammation, and energy production in muscle cells. They discuss a newer framework called Systemic Exertion Intolerance Disease that may help doctors diagnose and treat the condition more effectively.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

The Many Neuroprogressive Actions of Tryptophan Catabolites (TRYCATs) that may be Associated with the Pathophysiology of Neuro-Immune Disorders.

Morris, Gerwyn, Carvalho, André F, Anderson, George et al.·Current pharmaceutical design·2016

When the body has chronic inflammation and immune activation, it breaks down an amino acid called tryptophan differently than usual, creating byproducts called TRYCATs. Some of these byproducts can damage nerve cells and mitochondria (the energy factories in cells), while others may protect the brain but at the cost of causing brain fog and emotional problems. This review examines how this abnormal tryptophan breakdown might contribute to ME/CFS and other neurological conditions.

NeuroinflammationEnergy MetabolismImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Fecal Microbiota Transplantation and Its Usage in Neuropsychiatric Disorders.

Evrensel, Alper, Ceylan, Mehmet Emin·Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology·2016

This review examines fecal microbiota transplantation (FMT)—a treatment where healthy gut bacteria from a donor are transferred to a patient—and its potential use in treating brain and mental health conditions. While FMT is already proven effective for certain gut infections and inflammatory bowel diseases, researchers are exploring whether it might help with conditions like ME/CFS, autism, and Parkinson's disease. Early results are promising, but much more research is needed to understand if it's safe and effective long-term.

Gut MicrobiomeImmune System

E3 PreliminaryMechanismPEM unclearMechanistic

Serum BAFF and APRIL Levels, T-Lymphocyte Subsets, and Immunoglobulins after B-Cell Depletion Using the Monoclonal Anti-CD20 Antibody Rituximab in Myalgic Encephalopathy/Chronic Fatigue Syndrome.

Lunde, Sigrid, Kristoffersen, Einar K, Sapkota, Dipak et al.·PloS one·2016

Researchers tested whether a drug called rituximab, which removes B cells (a type of immune cell) from the blood, helps ME/CFS patients by examining immune system changes. They found that some ME/CFS patients had higher levels of a substance called BAFF that activates B cells, but this didn't predict who would improve with treatment. While some patients did get better with rituximab in earlier trials, the immune cell changes measured in this study didn't fully explain why.

Immune System

E3 PreliminaryCohortPEM unclearCase-Control

Coxiella burnetii dormancy in a fatal ten-year multisystem dysfunctional illness: case report.

Sukocheva, Olga A, Manavis, Jim, Kok, Tuck-Weng et al.·BMC infectious diseases·2016

This case report describes a young woman who developed severe, long-lasting illness after a Q fever infection and died 10 years later. After her death, researchers examined her tissues and found pieces of the bacteria (Coxiella burnetii) and its DNA still present in multiple organs, including her brain, heart, lungs, and spleen. This suggests that Q fever bacteria can persist in the body in a dormant or inactive form, potentially triggering ongoing illness.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Herpesviruses dUTPases: A New Family of Pathogen-Associated Molecular Pattern (PAMP) Proteins with Implications for Human Disease.

Williams, Marshall V, Cox, Brandon, Ariza, Maria Eugenia·Pathogens (Basel, Switzerland)·2016

This review examines how herpesvirus proteins called dUTPases may trigger harmful immune responses in ME/CFS and other diseases. Most adults carry dormant herpesviruses (like Epstein-Barr virus) that can reactivate throughout life. The researchers suggest that proteins released during reactivation may overstimulate the immune system, potentially worsening ME/CFS symptoms and inflammation.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Aluminum adjuvants of vaccines injected into the muscle: Normal fate, pathology and associated disease.

Gherardi, R K, Aouizerate, J, Cadusseau, J et al.·Morphologie : bulletin de l'Association des anatomistes·2016

This study reviews how aluminum compounds used in vaccines are processed by the body and whether they might cause long-term health problems. The researchers found that aluminum can persist in the body for extended periods, accumulate in organs, and in some cases may be associated with muscle pain, fatigue, and cognitive difficulties—a condition called macrophagic myofasciitis. The authors suggest that the long-term safety of aluminum-containing vaccines needs more careful examination.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

Autoantibody pain.

Goebel, Andreas·Autoimmunity reviews·2016

Your immune system sometimes makes proteins called autoantibodies that attack your own body's tissues and nerves. This review explores how these autoantibodies might cause pain directly by interfering with nerve signals, rather than just causing inflammation. Interestingly, ME/CFS appears to involve this type of autoantibody-related pain mechanism, which could open doors to new treatments for conditions that currently don't respond well to standard pain medications.

Immune System

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The autoimmune/inflammatory syndrome induced by adjuvants (ASIA)/Shoenfeld's syndrome: descriptive analysis of 300 patients from the international ASIA syndrome registry.

Stress, inflammation and natural treatments.

Dehydroepiandrosterone Research: Past, Current, and Future.

Investigation of mast cell toll-like receptor 3 in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Systemic Mastocytosis using the novel application of autoMACS magnetic separation and flow cytometry.

Non-linear dose-response of aluminium hydroxide adjuvant particles: Selective low dose neurotoxicity.

Detection of Urine Metabolites in a Rat Model of Chronic Fatigue Syndrome before and after Exercise.

[Effect of Acupuncture on the Expression of Transcription Factor T-bet/GATA-3 in Plasma of Rats with Chronic Fatigue Syndrome].

Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome.

NLRP3 inflammasome activation mediates fatigue-like behaviors in mice via neuroinflammation.

Two hundreds cases of ASIA syndrome following silicone implants: a comparative study of 30 years and a review of current literature.

Impaired calcium mobilization in natural killer cells from chronic fatigue syndrome/myalgic encephalomyelitis patients is associated with transient receptor potential melastatin 3 ion channels.

Efficacy of rintatolimod in the treatment of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME).

[Chronic fatigue syndrome: A new disorder?].

The Many Neuroprogressive Actions of Tryptophan Catabolites (TRYCATs) that may be Associated with the Pathophysiology of Neuro-Immune Disorders.

Fecal Microbiota Transplantation and Its Usage in Neuropsychiatric Disorders.

Serum BAFF and APRIL Levels, T-Lymphocyte Subsets, and Immunoglobulins after B-Cell Depletion Using the Monoclonal Anti-CD20 Antibody Rituximab in Myalgic Encephalopathy/Chronic Fatigue Syndrome.

Coxiella burnetii dormancy in a fatal ten-year multisystem dysfunctional illness: case report.

Herpesviruses dUTPases: A New Family of Pathogen-Associated Molecular Pattern (PAMP) Proteins with Implications for Human Disease.

Aluminum adjuvants of vaccines injected into the muscle: Normal fate, pathology and associated disease.

Autoantibody pain.

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