ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

881–900 of 2,420 studies

E3 PreliminaryMechanismPEM not requiredMechanistic

Non-linear dose-response of aluminium hydroxide adjuvant particles: Selective low dose neurotoxicity.

Crépeaux, Guillemette, Eidi, Housam, David, Marie-Odile et al.·Toxicology·2017

This study gave mice different amounts of aluminum hydroxide (a substance used in vaccines) injected into muscle and then checked their brains 6 months later. Surprisingly, the mice that received the lowest dose showed cognitive and movement changes, increased immune cell activity in the brain, and accumulated more aluminum in their brains—while the mice given higher doses did not. This unusual pattern suggests that aluminum's harmful effects may not simply follow the traditional "more dose = more harm" rule.

NeuroinflammationImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

FITNET's Internet-Based Cognitive Behavioural Therapy Is Ineffective and May Impede Natural Recovery in Adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. A Review.

Ghatineh, Simin, Vink, Mark·Behavioral sciences (Basel, Switzerland)·2017

This review examined a Dutch study called FITNET that claimed internet-based cognitive behavior therapy helped adolescents with ME/CFS recover at high rates. The reviewers found serious problems with how the study was designed and analyzed, including how they defined 'recovery' and that they didn't use objective measurements like activity monitors to confirm their results. The study actually found no meaningful difference between the therapy group and the usual care group at long-term follow-up, suggesting the treatment may not have worked as claimed.

Interventions

E3 PreliminaryMechanismPEM not requiredMechanistic

The variation of the 5-hydroxytryptamine system between chronic unpredictable mild stress rats and chronic fatigue syndrome rats induced by forced treadmill running.

Cao, Yin, Li, Qinglin·Neuroreport·2017

This study compared how serotonin (a brain chemical linked to mood and energy) works differently in two types of animal models—one mimicking stress-related depression and another mimicking ME/CFS. Surprisingly, the two conditions showed opposite patterns: the stress model had low serotonin levels, while the fatigue model had high serotonin levels, suggesting these conditions may involve different biological mechanisms even though both cause low activity and mood problems.

E3 PreliminaryMechanismPEM unclearMechanistic

Detection of Urine Metabolites in a Rat Model of Chronic Fatigue Syndrome before and after Exercise.

Shao, Changzhuan, Ren, Yiming, Wang, Zinan et al.·BioMed research international·2017

Researchers used rats exposed to stress and exercise to model ME/CFS and then measured chemicals in their urine before and after exercise. They found abnormalities in how the rats' bodies produce energy and process hormones, particularly in molecules called sphingosine and a hormone precursor called 21-hydroxypregnenolone. These findings suggest that ME/CFS may involve disrupted energy metabolism and problems with the body's stress-response system.

Energy MetabolismImmune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM requiredCross-Sectional

Exercise - induced changes in cerebrospinal fluid miRNAs in Gulf War Illness, Chronic Fatigue Syndrome and sedentary control subjects.

Baraniuk, James N, Shivapurkar, Narayan·Scientific reports·2017

Researchers studied brain fluid from people with Gulf War Illness and chronic fatigue syndrome (CFS) before and after exercise to understand why exercise makes symptoms worse. They found that exercise changes certain molecules called microRNAs in the brain fluid, and these changes were different in people with CFS compared to Gulf War Illness patients. This suggests that the biological reasons these conditions cause post-exertional exhaustion may be different, even though the symptoms look similar.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

A robust, single-injection method for targeted, broad-spectrum plasma metabolomics.

Li, Kefeng, Naviaux, Jane C, Bright, A Taylor et al.·Metabolomics : Official journal of the Metabolomic Society·2017

Researchers developed a new, efficient blood test that can measure over 600 different molecules (metabolites) in a single sample to help diagnose ME/CFS. The test was validated by showing it could correctly identify ME/CFS patients with 95% accuracy compared to healthy controls, even when tested again more than a year later by different researchers.

Biomarkers

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

XMRV and Public Health: The Retroviral Genome Is Not a Suitable Template for Diagnostic PCR, and Its Association with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Appears Unreliable.

Panelli, Simona, Lorusso, Lorenzo, Balestrieri, Alessandro et al.·Frontiers in public health·2017

This study investigated whether a virus called XMRV could be reliably detected in people with ME/CFS using standard testing methods. The researchers found that the tests designed to find this virus were not working properly—they were picking up false positives because the virus's genetic code looks very similar to parts of normal human DNA. This explains why different labs kept getting different results when trying to test for XMRV.

E3 PreliminaryReviewPEM unclearReview-Narrative

Epistemic injustice in healthcare encounters: evidence from chronic fatigue syndrome.

Blease, Charlotte, Carel, Havi, Geraghty, Keith·Journal of medical ethics·2017

Many doctors are uncertain whether ME/CFS is a real medical condition, and some patients report feeling disbelieved or suspected by healthcare providers. This study shows that patients with ME/CFS often experience unfair treatment in medical settings because doctors may not take their symptoms seriously. This type of dismissal—called epistemic injustice—can delay diagnosis and proper care for people with this serious illness.

Diagnostics

E3 PreliminaryDiagnosticPEM unclearCross-Sectional

Important factors to consider when treating children with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): perspectives of health professionals from specialist services.

Parslow, Roxanne M, Shaw, Alison, Haywood, Kirstie L et al.·BMC pediatrics·2017

This study asked specialist doctors and nurses who treat children with ME/CFS what they believe are the most important things to measure when checking how well a child is doing. The experts identified four key areas: symptoms (like fatigue and pain), physical ability to do things, participation in school and social activities, and emotional wellbeing. The goal is to create a better way to measure treatment success that matches what children and families actually care about.

E3 PreliminaryMechanismPEM not requiredMechanistic

Characterization of a protein-bound polysaccharide from Herba Epimedii and its metabolic mechanism in chronic fatigue syndrome.

Chi, Aiping, Shen, Zhimei, Zhu, Wenfei et al.·Journal of ethnopharmacology·2017

This study tested a natural compound extracted from Herba Epimedii (a traditional Chinese herb) to see if it could help treat chronic fatigue. Researchers gave the compound to rats with CFS-like symptoms and measured changes in their urine chemistry. They found that the treatment reversed several chemical imbalances associated with fatigue, suggesting the herb may work by restoring normal metabolism.

E3 PreliminaryCohortPEM unclearCase-Control

A thermal dysregulation problem after breast cancer surgery; what could be?

Rüstemova, Diana, Genc, Aysun, Bora, Gül et al.·Medicine·2017

A 41-year-old woman developed a persistent feeling of being cold after breast cancer surgery and was diagnosed with ME/CFS after other conditions were ruled out. She improved significantly with aerobic exercise done for at least 30 minutes, three or more days per week. This case suggests that abnormal temperature regulation—feeling unusually cold or hot—may be a symptom of ME/CFS that doctors should watch for.

E3 PreliminaryMechanismPEM requiredMechanistic

Neural consequences of post-exertion malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Cook, Dane B, Light, Alan R, Light, Kathleen C et al.·Brain, behavior, and immunity·2017

This study examined what happens in the brains of ME/CFS patients after exercise. Researchers asked 15 patients and 15 healthy people to exercise for 30 minutes, then used brain imaging to see how their brains worked before and 24 hours after exercise. ME/CFS patients' symptoms got much worse after exercise, their thinking and memory got worse, and their brain activity changed in specific ways—showing that exercise triggered real, measurable changes in how their brains functioned.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM unclear

Tenuous link between chronic fatigue syndrome and pyruvate dehydrogenase deficiency.

Bliksrud, Yngve Thomas·Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·2017

This study examined whether a specific metabolic enzyme problem called pyruvate dehydrogenase deficiency might be connected to ME/CFS. The researchers found only a weak or unclear link between this enzyme deficiency and ME/CFS symptoms, suggesting it is not a major cause of the illness for most patients.

Energy Metabolism

E3 PreliminaryCohortPEM not requiredCase-Control

CNS findings in chronic fatigue syndrome and a neuropathological case report.

Ferrero, Kimberly, Silver, Mitchell, Cocchetto, Alan et al.·Journal of investigative medicine : the official publication of the American Federation for Clinical Research·2017

This study examines brain tissue from one person who had ME/CFS and died, looking for physical changes that might explain the illness. Researchers found several abnormalities in the brain including areas of damaged nerve fibers, tangles similar to those seen in Alzheimer's disease, and deposits of a protein called amyloid. These findings suggest that ME/CFS may involve damage to the brain's structure and deserve further investigation.

Neuroinflammation

E3 PreliminaryMechanismPEM not requiredMechanistic

[Effect of Acupuncture on the Expression of Transcription Factor T-bet/GATA-3 in Plasma of Rats with Chronic Fatigue Syndrome].

Wang, Xiang-Yi, Liu, Chang-Zheng, Lei, Bo·Zhen ci yan jiu = Acupuncture research·2017

Researchers tested whether acupuncture could help rats with chronic fatigue syndrome by measuring changes in immune system markers. Acupuncture was applied to three specific points for two weeks, and the treated rats showed improved tiredness and swimming performance compared to untreated rats. The study suggests acupuncture may work by rebalancing immune system signals that become disrupted in ME/CFS.

Immune System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

RE: "MULTI-SITE CLINICAL ASSESSMENT OF MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME (MCAM): DESIGN AND IMPLEMENTATION OF A PROSPECTIVE/RETROSPECTIVE ROLLING COHORT STUDY".

American journal of epidemiology·2017

This study describes how researchers set up a large project to better understand and diagnose ME/CFS across multiple medical centers. The researchers created a system to carefully collect information about ME/CFS patients over time, combining both new patient data and information from medical records. This kind of organized approach helps scientists learn more about the condition and how to recognize it accurately.

E3 PreliminaryCohortPEM unclearObservational

Development of a recumbent isometric yoga program for patients with severe chronic fatigue syndrome/myalgic encephalomyelitis: A pilot study to assess feasibility and efficacy.

Oka, Takakazu, Wakita, Hisako, Kimura, Keishin·BioPsychoSocial medicine·2017

Researchers created a gentle yoga program done while lying down for people with severe ME/CFS who find it too difficult to sit. Over 3 months, 12 patients practiced this 20-minute program regularly and reported significant improvements in fatigue. Everyone in the study completed it safely with no serious side effects, and those who had previously tried sitting yoga preferred the lying-down version.

E3 PreliminaryPEM unclear

'Betwixt and between'; liminality in recovery stories from people with myalgic encephalomyelitis (ME) or chronic fatigue syndrome (CFS).

Brown, Brian, Huszar, Kate, Chapman, Rosemary·Sociology of health & illness·2017

This study interviewed 16 people who felt they had recovered from ME/CFS to understand what recovery actually feels like. The researchers found that recovery isn't simply returning to normal—instead, people experience a unique state where they're caught between being sick and being well. Even as they improved, participants continued using coping strategies like rest and pacing, and many felt they couldn't fully explain their experience to others or reconnect with the ME/CFS community they'd been part of.

E3 PreliminaryReviewPEM unclearReview-Narrative

Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome.

Morris, Gerwyn, Berk, Michael, Klein, Hans et al.·Molecular neurobiology·2017

This study proposes that ME/CFS may be caused by a harmful process called 'hypernitrosylation,' where a molecule called nitric oxide damages proteins in cells, particularly those responsible for producing energy and fighting infections. When this damage becomes chronic, it can disable the body's natural repair systems and trigger the immune system to attack the body's own proteins. The researchers suggest this process could explain many ME/CFS symptoms, including fatigue, cognitive problems, and how bacterial toxins may trigger or worsen the disease.

NeuroinflammationImmune System

E3 PreliminaryGuidelinePEM requiredGuideline

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer.

Rowe, Peter C, Underhill, Rosemary A, Friedman, Kenneth J et al.·Frontiers in pediatrics·2017

This guide helps doctors understand and diagnose ME/CFS in children and teenagers. ME/CFS causes extreme tiredness and makes it hard for young people to do physical or mental activities—with symptoms often getting worse after even small efforts and lasting for days or longer. The guide explains that there is no single test for ME/CFS, so doctors must diagnose it based on symptoms and by ruling out other conditions, and recommends that treatment focus on finding the right balance between rest and activity.

Post-Exertional Malaise

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Non-linear dose-response of aluminium hydroxide adjuvant particles: Selective low dose neurotoxicity.

FITNET's Internet-Based Cognitive Behavioural Therapy Is Ineffective and May Impede Natural Recovery in Adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. A Review.

The variation of the 5-hydroxytryptamine system between chronic unpredictable mild stress rats and chronic fatigue syndrome rats induced by forced treadmill running.

Detection of Urine Metabolites in a Rat Model of Chronic Fatigue Syndrome before and after Exercise.

Exercise - induced changes in cerebrospinal fluid miRNAs in Gulf War Illness, Chronic Fatigue Syndrome and sedentary control subjects.

A robust, single-injection method for targeted, broad-spectrum plasma metabolomics.

XMRV and Public Health: The Retroviral Genome Is Not a Suitable Template for Diagnostic PCR, and Its Association with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Appears Unreliable.

Epistemic injustice in healthcare encounters: evidence from chronic fatigue syndrome.

Important factors to consider when treating children with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): perspectives of health professionals from specialist services.

Characterization of a protein-bound polysaccharide from Herba Epimedii and its metabolic mechanism in chronic fatigue syndrome.

A thermal dysregulation problem after breast cancer surgery; what could be?

Neural consequences of post-exertion malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Tenuous link between chronic fatigue syndrome and pyruvate dehydrogenase deficiency.

CNS findings in chronic fatigue syndrome and a neuropathological case report.

[Effect of Acupuncture on the Expression of Transcription Factor T-bet/GATA-3 in Plasma of Rats with Chronic Fatigue Syndrome].

RE: "MULTI-SITE CLINICAL ASSESSMENT OF MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME (MCAM): DESIGN AND IMPLEMENTATION OF A PROSPECTIVE/RETROSPECTIVE ROLLING COHORT STUDY".

Development of a recumbent isometric yoga program for patients with severe chronic fatigue syndrome/myalgic encephalomyelitis: A pilot study to assess feasibility and efficacy.

'Betwixt and between'; liminality in recovery stories from people with myalgic encephalomyelitis (ME) or chronic fatigue syndrome (CFS).

Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer.

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