ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

881–900 of 2,422 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

Post-polio syndrome. Cases report and review of literature.

Pastuszak, Żanna, Stępień, Adam, Tomczykiewicz, Kazimierz et al.·Neurologia i neurochirurgia polska·2017

Post-polio syndrome (PPS) is a condition that affects some people who survived polio infection, typically appearing 15 or more years after the initial infection. Common symptoms include progressive muscle weakness, muscle wasting, joint pain, fatigue that interferes with daily activities, and abnormal sensations. This study examined three patients who developed PPS and used electrical testing of muscles (electromyography) to track how their condition changed over time.

E3 PreliminaryMechanismPEM unclearMechanistic

Detection of Urine Metabolites in a Rat Model of Chronic Fatigue Syndrome before and after Exercise.

Shao, Changzhuan, Ren, Yiming, Wang, Zinan et al.·BioMed research international·2017

Researchers used rats exposed to stress and exercise to model ME/CFS and then measured chemicals in their urine before and after exercise. They found abnormalities in how the rats' bodies produce energy and process hormones, particularly in molecules called sphingosine and a hormone precursor called 21-hydroxypregnenolone. These findings suggest that ME/CFS may involve disrupted energy metabolism and problems with the body's stress-response system.

Energy MetabolismImmune SystemPost-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCase-Control

A tiny tick can cause a big health problem.

John, Manuel, Raman, M, Ryan, Keith·Indian journal of ophthalmology·2017

This study describes rare cases of ticks biting people on the eyelid area in India. Ticks are tiny bugs that can carry serious diseases. The doctors had to carefully remove the ticks to avoid leaving parts behind, which could cause infection. The study highlights that tick-borne diseases, including ones that can cause chronic fatigue and other long-term health problems, are becoming more common in India and need prompt treatment.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Same, Same But Different? Cognitive Behavioural Treatment Approaches for Paediatric CFS/ME and Depression.

Loades, M E, Chalder, T·Behavioural and cognitive psychotherapy·2017

Many young people with ME/CFS also experience depression, and both conditions can be treated with a talking therapy called cognitive behavioural therapy (CBT). This paper compares how CBT is used for these two conditions in children and teenagers, explaining that while the approaches share some similarities, they focus on different problems and use different strategies to help each condition.

Interventions

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Simultaneous determination of multiple bioactive components of Bu-zhong-yi-qi-tang in rat tissues by LC-MS/MS: Application to a tissue distribution study.

He, Min, Chen, Wenwen, Wang, Mengmeng et al.·Journal of chromatography. B, Analytical technologies in the biomedical and life sciences·2017

Researchers developed a precise laboratory test to measure seven active ingredients from Bu-zhong-yi-qi-tang, a traditional herbal medicine used in East Asia for digestive problems, cancer, and chronic fatigue. They gave this herb to rats and tracked where these ingredients ended up in the body, finding they concentrated mainly in the digestive system.

E3 PreliminaryMechanismPEM requiredCross-Sectional

Exercise - induced changes in cerebrospinal fluid miRNAs in Gulf War Illness, Chronic Fatigue Syndrome and sedentary control subjects.

Baraniuk, James N, Shivapurkar, Narayan·Scientific reports·2017

Researchers studied brain fluid from people with Gulf War Illness and chronic fatigue syndrome (CFS) before and after exercise to understand why exercise makes symptoms worse. They found that exercise changes certain molecules called microRNAs in the brain fluid, and these changes were different in people with CFS compared to Gulf War Illness patients. This suggests that the biological reasons these conditions cause post-exertional exhaustion may be different, even though the symptoms look similar.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

FITNET's Internet-Based Cognitive Behavioural Therapy Is Ineffective and May Impede Natural Recovery in Adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. A Review.

Ghatineh, Simin, Vink, Mark·Behavioral sciences (Basel, Switzerland)·2017

This review examined a Dutch study called FITNET that claimed internet-based cognitive behavior therapy helped adolescents with ME/CFS recover at high rates. The reviewers found serious problems with how the study was designed and analyzed, including how they defined 'recovery' and that they didn't use objective measurements like activity monitors to confirm their results. The study actually found no meaningful difference between the therapy group and the usual care group at long-term follow-up, suggesting the treatment may not have worked as claimed.

Interventions

E3 PreliminaryGuidelinePEM requiredGuideline

Myalgic encephalomyelitis: International Consensus Criteria.

Journal of internal medicine·2017

This guideline establishes internationally agreed-upon criteria for diagnosing ME/CFS, helping doctors around the world recognize the condition consistently. It brings together expert knowledge to create clear standards for who has ME/CFS based on symptoms like post-exertional malaise (worsening after activity), sleep problems, cognitive difficulties, and pain. Having a shared definition makes it easier for patients to get accurate diagnoses and for researchers to study the same condition across different countries.

Post-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCase-Control

Two hundreds cases of ASIA syndrome following silicone implants: a comparative study of 30 years and a review of current literature.

Colaris, Maartje J L, de Boer, Mintsje, van der Hulst, Rene R et al.·Immunologic research·2017

This study compared 200 patients with silicone breast implants who developed autoimmune and inflammatory symptoms (a condition called ASIA) across two time periods—100 patients in 2014 and 100 historical patients from the 1980s–1990s. The researchers found that the symptoms remained similar over 30 years, including fatigue, joint pain, brain fog, and fever. About half of the patients who had their implants removed experienced symptom improvement.

Immune SystemPost-Exertional Malaise

E3 PreliminaryGuidelinePEM requiredGuideline

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer.

Rowe, Peter C, Underhill, Rosemary A, Friedman, Kenneth J et al.·Frontiers in pediatrics·2017

This guide helps doctors understand and diagnose ME/CFS in children and teenagers. ME/CFS causes extreme tiredness and makes it hard for young people to do physical or mental activities—with symptoms often getting worse after even small efforts and lasting for days or longer. The guide explains that there is no single test for ME/CFS, so doctors must diagnose it based on symptoms and by ruling out other conditions, and recommends that treatment focus on finding the right balance between rest and activity.

Post-Exertional Malaise

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Inducing Somatic Symptoms in Functional Syndrome Patients: Effects of Manipulating State Negative Affect.

Van Den Houte, Maaike, Bogaerts, Katleen, Van Diest, Ilse et al.·Psychosomatic medicine·2017

This study looked at whether negative emotions can trigger or worsen physical symptoms in people with ME/CFS and fibromyalgia. Researchers showed patients and healthy people emotionally negative, neutral, and positive pictures, then asked them to report what physical symptoms they felt. Patients with ME/CFS and fibromyalgia reported more symptoms after viewing negative pictures, while healthy people did not. The effect was stronger in patients who had difficulty recognizing their own feelings or who became deeply absorbed in things.

E3 PreliminaryCohortPEM unclearObservational

Development of a recumbent isometric yoga program for patients with severe chronic fatigue syndrome/myalgic encephalomyelitis: A pilot study to assess feasibility and efficacy.

Oka, Takakazu, Wakita, Hisako, Kimura, Keishin·BioPsychoSocial medicine·2017

Researchers created a gentle yoga program done while lying down for people with severe ME/CFS who find it too difficult to sit. Over 3 months, 12 patients practiced this 20-minute program regularly and reported significant improvements in fatigue. Everyone in the study completed it safely with no serious side effects, and those who had previously tried sitting yoga preferred the lying-down version.

E3 PreliminaryCohortPEM not requiredCase-Control

CNS findings in chronic fatigue syndrome and a neuropathological case report.

Ferrero, Kimberly, Silver, Mitchell, Cocchetto, Alan et al.·Journal of investigative medicine : the official publication of the American Federation for Clinical Research·2017

This study examines brain tissue from one person who had ME/CFS and died, looking for physical changes that might explain the illness. Researchers found several abnormalities in the brain including areas of damaged nerve fibers, tangles similar to those seen in Alzheimer's disease, and deposits of a protein called amyloid. These findings suggest that ME/CFS may involve damage to the brain's structure and deserve further investigation.

Neuroinflammation

E3 PreliminaryMechanismPEM unclearObservational

Cardiac sympathetic innervation associates with autonomic dysfunction in chronic fatigue syndrome - a pilot study.

Petrides, George, Zalewski, Pawel, McCulloch, David et al.·Fatigue : biomedicine, health & behavior·2017

This study looked at how the nervous system controls the heart in people with ME/CFS, focusing on a specific part called the sympathetic nervous system. Researchers used specialized imaging to examine nerve connections in the heart and compared them to problems with autonomic function (the automatic nervous system that controls heart rate and blood pressure). The findings suggest that differences in heart nerve connections may be related to why some ME/CFS patients experience autonomic symptoms like dizziness and heart rate changes.

Autonomic Nervous System

E3 PreliminaryBehavioralPEM unclearCross-Sectional

'It's personal to me': A qualitative study of depression in young people with CFS/ME.

Taylor, Anna K, Loades, Maria, Brigden, Amberly Lc et al.·Clinical child psychology and psychiatry·2017

This study talked with nine young people (aged 13-17) who have ME/CFS and depression to understand how these two conditions connect. Most young people felt that ME/CFS caused their depression because the illness stopped them doing activities they loved and changed their daily lives. Many also noticed that feeling sad made their ME/CFS symptoms worse, creating a difficult cycle. The researchers found that different combinations of treatments—like talking therapy, medicine, and careful activity planning—worked best for different people.

E3 PreliminaryGuidelinePEM not requiredGuideline

Group 6. Modalities and frequency of monitoring of patients with adrenal insufficiency. Patient education.

Guignat, Laurence, Proust-Lemoine, Emmanuelle, Reznik, Yves et al.·Annales d'endocrinologie·2017

This guideline explains how people with adrenal insufficiency (a condition where the body cannot make enough cortisol) should be monitored by their doctors and what they should learn to manage their condition safely. Patients need regular check-ups, should learn how to recognize warning signs of a crisis, know how to adjust their medication, and be able to give themselves emergency injections. The guideline emphasizes helping patients become independent in managing their illness and mentions that special care programs may help people with chronic fatigue avoid taking too much cortisol replacement.

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

'It feels sometimes like my house has burnt down, but I can see the sky': A qualitative study exploring patients' views of cognitive behavioural therapy for chronic fatigue syndrome.

Picariello, Federica, Ali, Sheila, Foubister, Caroline et al.·British journal of health psychology·2017

This study looked at what 13 ME/CFS patients thought about cognitive behavioural therapy (CBT), a talking therapy that helps people change unhelpful thinking patterns and behaviors. Most patients were satisfied with CBT and felt better, though not completely recovered. The study found that the personal support from a therapist and accepting that ME/CFS involves both physical and mental factors were important for success.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

The Neuroinflammatory Etiopathology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Glassford, Julian A G·Frontiers in physiology·2017

This article reviews research suggesting that ME/CFS may result from problems in how the nervous system and immune system interact. The author discusses how physical strain on the spine and nerves, combined with prolonged infections and immune activation, may trigger a chain reaction of inflammation in the brain and throughout the body. This inflammation can affect energy production, hormone balance, and how the body processes pain.

Neuroinflammation

E3 PreliminaryReviewPEM unclearReview-Narrative

Epistemic injustice in healthcare encounters: evidence from chronic fatigue syndrome.

Blease, Charlotte, Carel, Havi, Geraghty, Keith·Journal of medical ethics·2017

Many doctors are uncertain whether ME/CFS is a real medical condition, and some patients report feeling disbelieved or suspected by healthcare providers. This study shows that patients with ME/CFS often experience unfair treatment in medical settings because doctors may not take their symptoms seriously. This type of dismissal—called epistemic injustice—can delay diagnosis and proper care for people with this serious illness.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Emotional conflict processing in adolescent chronic fatigue syndrome: A pilot study using functional magnetic resonance imaging.

Wortinger, Laura Anne, Endestad, Tor, Melinder, Annika Maria D et al.·Journal of clinical and experimental neuropsychology·2017

This study looked at how the brains of teenagers with ME/CFS process emotions and handle conflicting information. Researchers used brain imaging to watch what happened when young people with ME/CFS and healthy teenagers tried to identify emotions in faces while being distracted by conflicting words. Teenagers with ME/CFS showed weaker brain responses in areas that handle emotions and decision-making, and their brain activity was linked to how severe their fatigue was.

Cognitive Impairment

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Post-polio syndrome. Cases report and review of literature.

Detection of Urine Metabolites in a Rat Model of Chronic Fatigue Syndrome before and after Exercise.

A tiny tick can cause a big health problem.

Same, Same But Different? Cognitive Behavioural Treatment Approaches for Paediatric CFS/ME and Depression.

Simultaneous determination of multiple bioactive components of Bu-zhong-yi-qi-tang in rat tissues by LC-MS/MS: Application to a tissue distribution study.

Exercise - induced changes in cerebrospinal fluid miRNAs in Gulf War Illness, Chronic Fatigue Syndrome and sedentary control subjects.

FITNET's Internet-Based Cognitive Behavioural Therapy Is Ineffective and May Impede Natural Recovery in Adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. A Review.

Myalgic encephalomyelitis: International Consensus Criteria.

Two hundreds cases of ASIA syndrome following silicone implants: a comparative study of 30 years and a review of current literature.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer.

Inducing Somatic Symptoms in Functional Syndrome Patients: Effects of Manipulating State Negative Affect.

Development of a recumbent isometric yoga program for patients with severe chronic fatigue syndrome/myalgic encephalomyelitis: A pilot study to assess feasibility and efficacy.

CNS findings in chronic fatigue syndrome and a neuropathological case report.

Cardiac sympathetic innervation associates with autonomic dysfunction in chronic fatigue syndrome - a pilot study.

'It's personal to me': A qualitative study of depression in young people with CFS/ME.

Group 6. Modalities and frequency of monitoring of patients with adrenal insufficiency. Patient education.

'It feels sometimes like my house has burnt down, but I can see the sky': A qualitative study exploring patients' views of cognitive behavioural therapy for chronic fatigue syndrome.

The Neuroinflammatory Etiopathology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Epistemic injustice in healthcare encounters: evidence from chronic fatigue syndrome.

Emotional conflict processing in adolescent chronic fatigue syndrome: A pilot study using functional magnetic resonance imaging.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research