ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

541–560 of 742 studies

My experience with ME/CFS and implications: A personal narrative.

Sirotiak, Zoe·Work (Reading, Mass.)·2023

This article shares the personal story of a young woman who is also a physical therapist and developed ME/CFS after a COVID-19 infection. She describes how the condition dramatically changed her life and how healthcare providers, including rehabilitation specialists, often lack the knowledge needed to properly help ME/CFS patients. The author highlights that ME/CFS remains poorly understood and undertreated, with few proven treatments available.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM requiredObservational

Sex-Dependent Transcriptional Changes in Response to Stress in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Project.

Gamer, Jackson, Van Booven, Derek J, Zarnowski, Oskar et al.·International journal of molecular sciences·2023

This study looked at how genes behave differently in men and women with ME/CFS when their bodies are stressed by exercise. Researchers tested blood samples from 33 ME/CFS patients and 34 healthy people before, during, and after exercise. They found that men and women with ME/CFS showed different patterns of gene activity in response to exercise—men's immune systems showed more dramatic changes, while women's genes related to stress response and virus handling showed bigger changes.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Towards a Better Understanding of the Complexities of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID.

Tate, Warren P, Walker, Max O M, Peppercorn, Katie et al.·International journal of molecular sciences·2023

ME/CFS is a complex illness that typically starts after a viral infection, though other stressful events can also trigger it. This review explains that different patients experience different combinations of symptoms and respond differently to treatments—what helps one person may not help another. The authors discuss how the immune system may shift from a temporary response to a lasting problem, and how the brain's immune system may cause the neurological symptoms people experience.

NeuroinflammationImmune SystemPost-Exertional Malaise

E3 PreliminaryBehavioralPEM requiredCase-Control

A patient who recovered from post-COVID myalgic encephalomyelitis/chronic fatigue syndrome: a case report.

Oka, Takakazu·BioPsychoSocial medicine·2023

This case report describes a nurse who developed ME/CFS symptoms after recovering from COVID-19, including severe fatigue, pain, brain fog, and heart palpitations that lasted over 6 months. She received treatment combining dietary advice, supplements, behavioral strategies, exercise conditioning, and two medications (amitriptyline and a Japanese herbal medicine called hochuekkito), and eventually recovered fully and returned to work. This is the first detailed report showing that someone with post-COVID ME/CFS can recover with comprehensive multimodal treatment.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM requiredMechanistic

Post-COVID exercise intolerance is associated with capillary alterations and immune dysregulations in skeletal muscles.

Aschman, Tom, Wyler, Emanuel, Baum, Oliver et al.·Acta neuropathologica communications·2023

Researchers examined muscle tissue from people with long COVID who experience fatigue and worsening symptoms after activity. They found that these patients had fewer blood vessels in their muscles, thicker vessel walls, and signs of immune cells that might have been triggered by the initial infection. These physical changes in the muscle's blood supply could explain why exercise makes their symptoms worse.

Immune SystemPost-Exertional Malaise

E3 PreliminaryCohortPEM requiredCase-Control

A case of post-COVID-19 myalgic encephalomyelitis/chronic fatigue syndrome characterized by post-exertional malaise and low serum acylcarnitine level.

Jinushi, Ryuhei, Nishiguchi, Sho, Masuda, Sakue et al.·Clinical case reports·2023

This study describes a patient who developed ME/CFS after recovering from COVID-19. The researchers found that this patient had lower-than-normal levels of acylcarnitine, a substance the body uses to produce energy. The study reviews existing research on how COVID-19 can lead to ME/CFS, a condition that causes severe fatigue and symptoms that worsen after physical activity.

BiomarkersPost-Exertional Malaise

E3 PreliminaryCommentaryPEM requiredEditorial

The Role of Psychotherapy in the Care of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Grande, Tilman, Grande, Bettina, Gerner, Patrick et al.·Medicina (Kaunas, Lithuania)·2023

This article discusses how talking therapy (psychotherapy) might help people with ME/CFS cope better, even though it cannot cure the disease itself. The authors emphasize that ME/CFS is a physical illness requiring physical treatments, and they highlight that post-exertional malaise (getting worse after activity) is a key symptom that therapists should understand. They propose a practical approach to therapy that respects these facts while still helping patients manage their emotional wellbeing.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic inflammation, neuroglial dysfunction, and plasmalogen deficiency as a new pathobiological hypothesis addressing the overlap between post-COVID-19 symptoms and myalgic encephalomyelitis/chronic fatigue syndrome.

Chaves-Filho, Adriano Maia, Braniff, Olivia, Angelova, Angelina et al.·Brain research bulletin·2023

This study examines how long COVID and ME/CFS may share similar problems in the body, particularly chronic inflammation (ongoing swelling and immune activation) and low levels of plasmalogens, which are protective fats found in cell membranes. The researchers propose that restoring plasmalogen levels through dietary supplements could potentially help reduce symptoms like fatigue, brain fog, and post-exertional malaise in both conditions.

NeuroinflammationPost-Exertional Malaise

E3 PreliminaryReviewPEM requiredReview-Narrative

A review of cytokine-based pathophysiology of Long COVID symptoms.

Low, Russell N, Low, Ryan J, Akrami, Athena·Frontiers in medicine·2023

This review examines how Long COVID may develop through a chain reaction of immune system problems. When the virus infects the body, it can trigger ongoing inflammation that affects both the immune system and the brain, potentially causing blood clots in small vessels. This combination may explain symptoms like fatigue, brain fog, and pain that Long COVID and ME/CFS patients experience.

NeuroinflammationPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

The Long Road of Long COVID: Specific Considerations for the Allergist/Immunologist.

Bellanti, Joseph A, Novak, Peter, Faitelson, Yoram et al.·The journal of allergy and clinical immunology. In practice·2023

Long COVID is a condition that develops after a COVID-19 infection and can cause symptoms affecting many parts of the body, including heart problems, blood clots, fatigue, and autoimmune issues. This review examines what causes Long COVID and which patients are most at risk, noting that certain groups like Hispanic and Latino communities face higher rates. The authors highlight that while vaccines help prevent severe acute COVID, we still need more research to understand how they affect Long COVID development and progression.

Immune SystemPost-Exertional Malaise

E3 PreliminaryCohortPEM unclearCase-Control

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: First Described Complication after Gam-COVID-Vac Vaccine.

Manysheva, Ksenia, Sherman, Mikhail, Zhukova, Natalia et al.·Psychiatria Danubina·2022

This report describes one case of a 25-year-old woman who developed ME/CFS symptoms about 10 days after receiving the Sputnik V COVID-19 vaccine. She experienced severe fatigue, muscle pain, and difficulty moving. This is the first documented case linking ME/CFS to this particular vaccine, though it remains unclear whether the vaccine caused the condition or if it occurred by coincidence.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Perspective: Drawing on Findings From Critical Illness to Explain Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Stanculescu, Dominic, Bergquist, Jonas·Frontiers in medicine·2022

This paper suggests that ME/CFS might develop through similar biological problems seen in people with severe critical illnesses. The researchers propose that four interconnected issues—reduced blood flow to tissues, damage to the gut lining, problems with pituitary gland function, and low thyroid hormone activity—could work together to create a cycle that keeps ME/CFS going. Understanding these connections could help develop better treatments.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

[Long COVID: nosographic aspects and clinical epidemiology].

Abrignani, Maurizio G, Maloberti, Alessandro, Temporelli, Pier Luigi et al.·Giornale italiano di cardiologia (2006)·2022

Long COVID is a condition where people experience ongoing symptoms weeks or months after recovering from COVID-19 infection. Symptoms can include fatigue, difficulty thinking clearly, shortness of breath, muscle pain, sleep problems, and reduced ability to do daily activities. This review looks at how common long COVID is, who is most likely to develop it, and what we currently know about the condition.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Proposed subtypes of post-COVID-19 syndrome (or long-COVID) and their respective potential therapies.

Yong, Shin Jie, Liu, Shiliang·Reviews in medical virology·2022

This review examines long COVID (persistent symptoms lasting months after COVID-19 infection) and proposes that it comes in six different subtypes, one of which is ME/CFS-like illness. The authors describe the symptoms and potential treatments for each subtype, helping doctors and patients better understand which type of long COVID a person might have. This framework could help lead to more targeted treatments since different subtypes may need different approaches.

Post-Exertional Malaise

E3 PreliminaryCommentaryPEM required

Letter: Could endothelial dysfunction and vascular damage contribute to pain, inflammation and post-exertional malaise in individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)?

Lubell, Jeffrey·Journal of translational medicine·2022

This editorial letter explores whether problems with blood vessel function and damage might explain some of the key symptoms of ME/CFS, including pain, inflammation, and post-exertional malaise (the exhaustion that follows physical activity). The author proposes that if blood vessels aren't working properly, they may not deliver enough oxygen and nutrients to tissues, which could trigger the symptoms many ME/CFS patients experience.

Post-Exertional Malaise

E3 PreliminaryReviewPEM requiredReview-Narrative

The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications.

Kell, Douglas B, Pretorius, Etheresia·The Biochemical journal·2022

This paper proposes that ME/CFS, Long COVID, and some other chronic diseases may be caused by a harmful cycle involving tiny blood clots blocking small blood vessels, followed by damage when blood flow returns. The authors suggest that this process creates harmful molecules called free radicals and triggers inflammation and other problems. They review existing evidence that treatments like antioxidants, anti-inflammatory drugs, and blood thinners might help address these underlying mechanisms.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM requiredMechanistic

Exosome-associated mitochondrial DNA from patients with myalgic encephalomyelitis/chronic fatigue syndrome stimulates human microglia to release IL-1β.

Tsilioni, Irene, Natelson, Benjamin, Theoharides, Theoharis C·The European journal of neuroscience·2022

This study found that after exercise, patients with ME/CFS have more pieces of DNA from their mitochondria (the energy-producing parts of cells) floating in their blood inside tiny particles called exosomes. When researchers tested these exosomes on immune cells in the lab, they triggered the release of IL-1β, a chemical that causes inflammation in the brain. This suggests that exercise might trigger a chain reaction involving these DNA-carrying particles that could contribute to ME/CFS symptoms.

NeuroinflammationImmune SystemPost-Exertional Malaise

E3 PreliminaryCommentaryPEM unclearEditorial

[Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Who Have Already Visited Some Medical Institutions: The Points of Diagnosis and Treatment].

Shimomura, Tokio·Brain and nerve = Shinkei kenkyu no shinpo·2022

ME/CFS is a debilitating condition characterized primarily by severe fatigue, but doctors currently have no reliable blood tests or biomarkers to definitively diagnose it. This editorial discusses how ME/CFS diagnosis and treatment require specialized medical knowledge, and notes that common treatments like vitamins and herbal medicines have not proven effective. The authors also observed ME/CFS-like symptoms in some COVID-19 patients, which has prompted renewed research into understanding how ME/CFS develops and finding better treatments.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

The Role of Kynurenine Pathway and NAD+ Metabolism in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Dehhaghi, Mona, Panahi, Hamed Kazemi Shariat, Kavyani, Bahar et al.·Aging and disease·2022

This review examines how tryptophan, an amino acid we get from food, is processed differently in people with ME/CFS. The body normally converts tryptophan into important substances like serotonin (which affects mood) and NAD+, an energy molecule. The authors propose that this conversion process may become overactive in ME/CFS, depleting NAD+ and making fatigue worse. They suggest that NAD+ supplements might help reduce fatigue and improve quality of life.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Dyspnea in Post-COVID Syndrome following Mild Acute COVID-19 Infections: Potential Causes and Consequences for a Therapeutic Approach.

Wirth, Klaus J, Scheibenbogen, Carmen·Medicina (Kaunas, Lithuania)·2022

Many people with post-COVID syndrome experience shortness of breath and chest pain, even though their lungs and heart are typically healthy. This study proposes that the problem may stem from overbreathing (hyperventilation) during exercise, combined with problems in how the body regulates breathing and uses energy in muscles. The authors suggest that overbreathing creates a harmful cascade inside cells—disrupting sodium and calcium balance—which worsens fatigue and breathing difficulties. Preventing overbreathing might be a way to help these patients recover.

Energy MetabolismPost-Exertional Malaise

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

My experience with ME/CFS and implications: A personal narrative.

Sex-Dependent Transcriptional Changes in Response to Stress in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Project.

Towards a Better Understanding of the Complexities of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID.

A patient who recovered from post-COVID myalgic encephalomyelitis/chronic fatigue syndrome: a case report.

Post-COVID exercise intolerance is associated with capillary alterations and immune dysregulations in skeletal muscles.

A case of post-COVID-19 myalgic encephalomyelitis/chronic fatigue syndrome characterized by post-exertional malaise and low serum acylcarnitine level.

The Role of Psychotherapy in the Care of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Chronic inflammation, neuroglial dysfunction, and plasmalogen deficiency as a new pathobiological hypothesis addressing the overlap between post-COVID-19 symptoms and myalgic encephalomyelitis/chronic fatigue syndrome.

A review of cytokine-based pathophysiology of Long COVID symptoms.

The Long Road of Long COVID: Specific Considerations for the Allergist/Immunologist.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: First Described Complication after Gam-COVID-Vac Vaccine.

Perspective: Drawing on Findings From Critical Illness to Explain Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

[Long COVID: nosographic aspects and clinical epidemiology].

Proposed subtypes of post-COVID-19 syndrome (or long-COVID) and their respective potential therapies.

Letter: Could endothelial dysfunction and vascular damage contribute to pain, inflammation and post-exertional malaise in individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)?

The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications.

Exosome-associated mitochondrial DNA from patients with myalgic encephalomyelitis/chronic fatigue syndrome stimulates human microglia to release IL-1β.

[Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Who Have Already Visited Some Medical Institutions: The Points of Diagnosis and Treatment].

The Role of Kynurenine Pathway and NAD+ Metabolism in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Dyspnea in Post-COVID Syndrome following Mild Acute COVID-19 Infections: Potential Causes and Consequences for a Therapeutic Approach.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research