ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

21–40 of 266 studies

E0 ConsensusPEM not requiredModerate confidenceEditorialEditor reviewed

Central nervous system abnormalities in fibromyalgia and chronic fatigue syndrome: new concepts in treatment.

Gur, Ali, Oktayoglu, Pelin·Current pharmaceutical design·2008

This review examines how ME/CFS and fibromyalgia may both involve problems in the nervous system—specifically in how the brain processes pain, manages stress hormones, and controls automatic body functions. The authors discuss why current treatments are limited and explore new medication approaches that target brain chemicals involved in pain and fatigue.

SleepAutonomic Nervous SystemCognitive Impairment

E0 ConsensusPEM unclearPreliminaryReview-NarrativeEditor reviewed

Approved and investigational uses of modafinil : an evidence-based review.

Kumar, Raminder·Drugs·2008

This review looked at studies testing modafinil, a medication that promotes wakefulness, in different conditions including sleep disorders and fatigue-related illnesses. The authors found that modafinil works well for approved conditions like narcolepsy and sleep apnea, but studies testing it for chronic fatigue syndrome were very small and gave unclear results. The medication can cause side effects like insomnia, headaches, and appetite loss, and may interact with other drugs.

SleepCognitive Impairment

E0 ConsensusPEM unclearModerate confidenceReview-NarrativeEditor reviewed

Review of clinical and psychobiological dimensions of the chronic fatigue syndrome: differentiation from depression and contribution of sleep dysfunctions.

Fischler, B·Sleep medicine reviews·1999

This review examined how ME/CFS differs from depression and what role sleep problems play in the condition. The researchers found that ME/CFS is a distinct illness with its own biological features—not just depression wearing a different mask. While sleep problems are common in ME/CFS, they don't fully explain why patients feel so exhausted and unwell.

Evidence Atlas

Evidence browser

Central nervous system abnormalities in fibromyalgia and chronic fatigue syndrome: new concepts in treatment.

Approved and investigational uses of modafinil : an evidence-based review.

Review of clinical and psychobiological dimensions of the chronic fatigue syndrome: differentiation from depression and contribution of sleep dysfunctions.

Fibromyalgia and chronic fatigue syndrome: similarities and differences.

Tuina therapy for patients with chronic fatigue syndrome: a randomized controlled trial.

Effectiveness of a brief multicomponent intervention to improve physical activity level and functional capacity in fibromyalgia and chronic fatigue syndrome (Synchronize+).

Efficacy of aquatic vs land-based therapy for pain management in women with fibromyalgia: a randomised controlled trial.

Acupoint massage at Shenque (CV 8) for chronic fatigue syndrome: a randomized controlled trial.

Effects of Yijinjing Qigongin Alleviating Fatigue, Sleep Quality, and Health Status on Patients with Chronic Fatigue Syndrome: A Randomized, Controlled, and Parallel Group Clinical Study.

The Qigong of Prolong Life With Nine Turn Method Relieve Fatigue, Sleep, Anxiety and Depression in Patients With Chronic Fatigue Syndrome: A Randomized Controlled Clinical Study.

Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.

Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.

[Effect of ginger-separated moxibustion on fatigue, sleep quality and depression in patients with chronic fatigue syndrome: a randomized controlled trial].

The effectiveness of cupping therapy on chronic fatigue syndrome: A single-blind randomized controlled trial.

The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT.

Qigong exercise for chronic fatigue syndrome.

Agomelatine but not melatonin improves fatigue perception: a longitudinal proof-of-concept study.

Pilot study investigating the utility of a specialized online symptom management program for individuals with myalgic encephalomyelitis/chronic fatigue syndrome as compared to an online meditation program.

Qigong exercise alleviates fatigue, anxiety, and depressive symptoms, improves sleep quality, and shortens sleep latency in persons with chronic fatigue syndrome-like illness.

[The use of melatonin in the treatment of chronic fatigue syndrome and circadian rhythm disorders in Parkinson's disease].

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

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